DegronMD

Uniprot ID: Q8N660

Source protein: Neuroblastoma breakpoint family member 15

Source gene: NBPF15

Class: DEG_APCC_DBOX_1

Location: 499:507

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9841

ASA_SCORE: 84.4778

COIL: 0.4392

CONS_SCORE: 0.6003

DSS_SCORE: 0.5083

HELIX: 0.5361

FCONS_SCORE: 1.1844

RIG_SCORE: 0.7764

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G492D	DO227516	LAML	ICGC	SRELLEVVE	DEG_APCC_DBOX_1	0.1389
p.G492D	DO224570	LUSC	ICGC	SRELLEVVE	DEG_APCC_DBOX_1	0.1389
p.G492D	DO224613	LUSC	ICGC	SRELLEVVE	DEG_APCC_DBOX_1	0.1389
p.G492D	DO52342	LUSC	ICGC	SRELLEVVE	DEG_APCC_DBOX_1	0.1389
p.G492D	DO52343	LUSC	ICGC	SRELLEVVE	DEG_APCC_DBOX_1	0.1389
p.G492D	DO229173	THCA	ICGC	SRELLEVVE	DEG_APCC_DBOX_1	0.1389
p.G492D	DO229234	THCA	ICGC	SRELLEVVE	DEG_APCC_DBOX_1	0.1389
p.V505A	DO229167	THCA	ICGC	SRELLEVVE	DEG_APCC_DBOX_1	0.5825
p.V505A	DO229259	THCA	ICGC	SRELLEVVE	DEG_APCC_DBOX_1	0.5825

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86T75	Neuroblastoma breakpoint family member 11	DEG_APCC_DBOX_1	770:778	SRELLEVVE	APC,CDC20,FZR1	0.7458	More...
Q8N660	Neuroblastoma breakpoint family member 15	DEG_APCC_DBOX_1	499:507	SRELLEVVE	APC,CDC20,FZR1	0.9841	More...
Q3BBV2	Putative neuroblastoma breakpoint family member 8	DEG_APCC_DBOX_1	735:743	SRELLEVVE	APC,CDC20,FZR1	0.9187	More...
Q5TI25	Neuroblastoma breakpoint family member 14	DEG_APCC_DBOX_1	430:438	SRELLEVVE	APC,CDC20,FZR1	0.6661	More...
Q5TI25	Neuroblastoma breakpoint family member 14	DEG_APCC_DBOX_1	749:757	SRELLEVVE	APC,CDC20,FZR1	0.9535	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons