DegronMD - Q86T96(RNF180)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R392T	TCGA-04-1655	OV	TCGA	ERSKLKNLR	DEG_APCC_DBOX_1	376:384	Mutation rewiring degron network	0.1111
p.R392T	DO29860	OV	ICGC	ERSKLKNLR	DEG_APCC_DBOX_1	376:384	Mutation rewiring degron network	0.1111
p.N382D	TCGA-22-5481	LUSC	TCGA	ERSKLKNLR	DEG_APCC_DBOX_1	376:384	Mutation altering degron motif	0.5821
p.N382D	DO27160	LUSC	ICGC	ERSKLKNLR	DEG_APCC_DBOX_1	376:384	Mutation altering degron motif	0.5821
p.R384T	TCGA-55-8208	LUAD	TCGA	ERSKLKNLR	DEG_APCC_DBOX_1	376:384	Mutation altering degron motif	0.6765
p.R384T	DO51192	LUAD	ICGC	ERSKLKNLR	DEG_APCC_DBOX_1	376:384	Mutation altering degron motif	0.6765
p.R388Q	TCGA-E6-A1LX	UCEC	TCGA	ERSKLKNLR	DEG_APCC_DBOX_1	376:384	Mutation rewiring degron network	0.2222
p.R388Q	TCGA-EO-A3B0	UCEC	TCGA	ERSKLKNLR	DEG_APCC_DBOX_1	376:384	Mutation rewiring degron network	0.2222
p.R388Q	DO219773	UCEC	ICGC	ERSKLKNLR	DEG_APCC_DBOX_1	376:384	Mutation rewiring degron network	0.2222
p.R388Q	DO41020	UCEC	ICGC	ERSKLKNLR	DEG_APCC_DBOX_1	376:384	Mutation rewiring degron network	0.2222
p.R392I	DO8264	COAD	ICGC	ERSKLKNLR	DEG_APCC_DBOX_1	376:384	Mutation rewiring degron network	0.1111
p.W393C	DO229036	LICA	ICGC	ERSKLKNLR	DEG_APCC_DBOX_1	376:384	Mutation rewiring degron network	0.0833
p.R390C	DO229264	THCA	ICGC	ERSKLKNLR	DEG_APCC_DBOX_1	376:384	Mutation rewiring degron network	0.1667
p.R388G	DO43338	UCEC	ICGC	ERSKLKNLR	DEG_APCC_DBOX_1	376:384	Mutation rewiring degron network	0.2222
p.R371T	SIDM01155	Glioma	GDSC	ERSKLKNLR	DEG_APCC_DBOX_1	376:384	Mutation rewiring degron network	0.1944
p.R371T	ACH-000437	Brain Cancer	CCLE	ERSKLKNLR	DEG_APCC_DBOX_1	376:384	Mutation rewiring degron network	0.1944
p.R371T	SW1088	central nervous system	COSMIC	ERSKLKNLR	DEG_APCC_DBOX_1	376:384	Mutation rewiring degron network	0.1944
p.L383P	ACH-001610	Brain Cancer	CCLE	ERSKLKNLR	DEG_APCC_DBOX_1	376:384	Mutation altering degron motif	0.7582

Kaplan plot for RNF180 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RNF180

UniProt ID: Q86T96

Entrez ID: 285671

Protein name: E3 ubiquitin-protein ligase RNF180 (EC 2.3.2.27) (RING finger protein 180) (RING-type E3 ubiquitin transferase RNF180)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RNF180 in