DegronMD

Uniprot ID: Q86T96

Source protein: E3 ubiquitin-protein ligase RNF180

Source gene: RNF180

Class: DEG_APCC_DBOX_1

Location: 376:384

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5406

ASA_SCORE: 114.3778

COIL: 0.2546

CONS_SCORE: 0.5973

DSS_SCORE: 0.5998

HELIX: 0.7529

FCONS_SCORE: 1.0522

RIG_SCORE: 0.7684

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R392T	TCGA-04-1655	OV	TCGA	ERSKLKNLR	DEG_APCC_DBOX_1	0.1111
p.R392T	DO29860	OV	ICGC	ERSKLKNLR	DEG_APCC_DBOX_1	0.1111
p.N382D	TCGA-22-5481	LUSC	TCGA	ERSKLKNLR	DEG_APCC_DBOX_1	0.5821
p.N382D	DO27160	LUSC	ICGC	ERSKLKNLR	DEG_APCC_DBOX_1	0.5821
p.R384T	TCGA-55-8208	LUAD	TCGA	ERSKLKNLR	DEG_APCC_DBOX_1	0.6765
p.R384T	DO51192	LUAD	ICGC	ERSKLKNLR	DEG_APCC_DBOX_1	0.6765
p.R388Q	TCGA-E6-A1LX	UCEC	TCGA	ERSKLKNLR	DEG_APCC_DBOX_1	0.2222
p.R388Q	TCGA-EO-A3B0	UCEC	TCGA	ERSKLKNLR	DEG_APCC_DBOX_1	0.2222
p.R388Q	DO219773	UCEC	ICGC	ERSKLKNLR	DEG_APCC_DBOX_1	0.2222
p.R388Q	DO41020	UCEC	ICGC	ERSKLKNLR	DEG_APCC_DBOX_1	0.2222
p.R392I	DO8264	COAD	ICGC	ERSKLKNLR	DEG_APCC_DBOX_1	0.1111
p.W393C	DO229036	LICA	ICGC	ERSKLKNLR	DEG_APCC_DBOX_1	0.0833
p.R390C	DO229264	THCA	ICGC	ERSKLKNLR	DEG_APCC_DBOX_1	0.1667
p.R388G	DO43338	UCEC	ICGC	ERSKLKNLR	DEG_APCC_DBOX_1	0.2222
p.R371T	SIDM01155	Glioma	GDSC	ERSKLKNLR	DEG_APCC_DBOX_1	0.1944
p.R371T	ACH-000437	Brain Cancer	CCLE	ERSKLKNLR	DEG_APCC_DBOX_1	0.1944
p.R371T	SW1088	central_nervous_system	COSMIC	ERSKLKNLR	DEG_APCC_DBOX_1	0.1944
p.L383P	ACH-001610	Brain Cancer	CCLE	ERSKLKNLR	DEG_APCC_DBOX_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86T96	E3 ubiquitin-protein ligase RNF180	DEG_APCC_DBOX_1	376:384	ERSKLKNLR	APC,CDC20,FZR1	0.5406	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons