PRUNE1
UniProt ID: Q86TP1
Entrez ID: 58497
Protein name: Exopolyphosphatase PRUNE1 (EC 3.6.1.1) (Drosophila-related expressed sequence 17) (DRES-17) (DRES17) (HTcD37) (Protein prune homolog 1) (hPrune)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1. Plays a role in the regulation of neurogenesis (PubMed:28334956). Involved in the regulation of...
FUNCTION: Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1. Plays a role in the regulation of neurogenesis (PubMed:28334956). Involved in the regulation of microtubule polymerization (PubMed:28334956). {ECO:0000269|PubMed:10602478, ECO:0000269|PubMed:11687967, ECO:0000269|PubMed:14998490, ECO:0000269|PubMed:16428445, ECO:0000269|PubMed:17906697, ECO:0000269|PubMed:28334956}.
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GO - Biological processes (BP):
regulation of microtubule polymerization [GO:0031113]; regulation of neurogenesis [GO:0050767]...
regulation of microtubule polymerization [GO:0031113]; regulation of neurogenesis [GO:0050767]
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GO - Molecular function (MF):
exopolyphosphatase activity [GO:0004309]; inorganic diphosphatase activity [GO:0004427]; metal ion binding [GO:0046872]; phosphatase activity [GO:0016791]; tubulin binding [GO:0015631]...
exopolyphosphatase activity [GO:0004309]; inorganic diphosphatase activity [GO:0004427]; metal ion binding [GO:0046872]; phosphatase activity [GO:0016791]; tubulin binding [GO:0015631]
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GO - Cellular component (CC):
cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]...
cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]
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PRUNE1
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Kaplan plot for PRUNE1 in
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*NOTE: the Kaplan plots were collected from OncoLnc