DegronMD - Q86TV6(TTC7B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P653T	TCGA-C8-A273	BRCA	TCGA	DRRQLNTIT	DEG_APCC_DBOX_1	638:646	Mutation rewiring degron network	0.1389
p.P653T	DO4050	BRCA	ICGC	DRRQLNTIT	DEG_APCC_DBOX_1	638:646	Mutation rewiring degron network	0.1389
p.P653L	TCGA-GF-A6C9	SKCM	TCGA	DRRQLNTIT	DEG_APCC_DBOX_1	638:646	Mutation rewiring degron network	0.1389
p.P653L	TCGA-GV-A3QI	BLCA	TCGA	DRRQLNTIT	DEG_APCC_DBOX_1	638:646	Mutation rewiring degron network	0.1389
p.P653L	DO470	BLCA	ICGC	DRRQLNTIT	DEG_APCC_DBOX_1	638:646	Mutation rewiring degron network	0.1389
p.P653L	DO51254	SKCM	ICGC	DRRQLNTIT	DEG_APCC_DBOX_1	638:646	Mutation rewiring degron network	0.1389
p.R640Q	TCGA-L5-A4OO	ESCA	TCGA	DRRQLNTIT	DEG_APCC_DBOX_1	638:646	Mutation altering degron motif	0.6218
p.R640Q	DO222884	COCA	ICGC	DRRQLNTIT	DEG_APCC_DBOX_1	638:646	Mutation altering degron motif	0.6218
p.D652N	DO224882	BRCA	ICGC	DRRQLNTIT	DEG_APCC_DBOX_1	638:646	Mutation rewiring degron network	0.1667
p.S651R	DO228978	LICA	ICGC	DRRQLNTIT	DEG_APCC_DBOX_1	638:646	Mutation blocking phosphorylation signal	0.6389
p.A637T	DO228428	MALY	ICGC	DRRQLNTIT	DEG_APCC_DBOX_1	638:646	Mutation rewiring degron network	0.3056
p.F650S	SIDM00447	B-Lymphoblastic Leukemia	GDSC	DRRQLNTIT	DEG_APCC_DBOX_1	638:646	Mutation rewiring degron network	0.2222
p.F650S	ACH-000960	Leukemia	CCLE	DRRQLNTIT	DEG_APCC_DBOX_1	638:646	Mutation rewiring degron network	0.2222
p.F650S	REH	haematopoietic and lymphoid tissue	COSMIC	DRRQLNTIT	DEG_APCC_DBOX_1	638:646	Mutation rewiring degron network	0.2222
p.E654G	SIDM01617	Endometrial Carcinoma	GDSC	DRRQLNTIT	DEG_APCC_DBOX_1	638:646	Mutation rewiring degron network	0.1111
p.E654G	ACH-000994	Endometrial/Uterine Cancer	CCLE	DRRQLNTIT	DEG_APCC_DBOX_1	638:646	Mutation rewiring degron network	0.1111

Kaplan plot for TTC7B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TTC7B

UniProt ID: Q86TV6

Entrez ID: 145567

Protein name: Tetratricopeptide repeat protein 7B (TPR repeat protein 7B) (Tetratricopeptide repeat protein 7-like-1) (TPR repeat protein 7-like-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TTC7B in