DegronMD

Uniprot ID: Q86TV6

Source protein: Tetratricopeptide repeat protein 7B

Source gene: TTC7B

Class: DEG_APCC_DBOX_1

Location: 638:646

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8935

ASA_SCORE: 54.7778

COIL: 0.3327

CONS_SCORE: 0.4152

DSS_SCORE: 0.4401

HELIX: 0.6529

FCONS_SCORE: 0.9784

RIG_SCORE: 0.7817

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P653T	TCGA-C8-A273	BRCA	TCGA	DRRQLNTIT	DEG_APCC_DBOX_1	0.1389
p.P653T	DO4050	BRCA	ICGC	DRRQLNTIT	DEG_APCC_DBOX_1	0.1389
p.P653L	TCGA-GF-A6C9	SKCM	TCGA	DRRQLNTIT	DEG_APCC_DBOX_1	0.1389
p.P653L	TCGA-GV-A3QI	BLCA	TCGA	DRRQLNTIT	DEG_APCC_DBOX_1	0.1389
p.P653L	DO470	BLCA	ICGC	DRRQLNTIT	DEG_APCC_DBOX_1	0.1389
p.P653L	DO51254	SKCM	ICGC	DRRQLNTIT	DEG_APCC_DBOX_1	0.1389
p.R640Q	TCGA-L5-A4OO	ESCA	TCGA	DRRQLNTIT	DEG_APCC_DBOX_1	0.6218
p.R640Q	DO222884	COCA	ICGC	DRRQLNTIT	DEG_APCC_DBOX_1	0.6218
p.D652N	DO224882	BRCA	ICGC	DRRQLNTIT	DEG_APCC_DBOX_1	0.1667
p.S651R	DO228978	LICA	ICGC	DRRQLNTIT	DEG_APCC_DBOX_1	0.6389
p.A637T	DO228428	MALY	ICGC	DRRQLNTIT	DEG_APCC_DBOX_1	0.3056
p.F650S	SIDM00447	B-Lymphoblastic Leukemia	GDSC	DRRQLNTIT	DEG_APCC_DBOX_1	0.2222
p.F650S	ACH-000960	Leukemia	CCLE	DRRQLNTIT	DEG_APCC_DBOX_1	0.2222
p.F650S	REH	haematopoietic_and_lymphoid_tissue	COSMIC	DRRQLNTIT	DEG_APCC_DBOX_1	0.2222
p.E654G	SIDM01617	Endometrial Carcinoma	GDSC	DRRQLNTIT	DEG_APCC_DBOX_1	0.1111
p.E654G	ACH-000994	Endometrial/Uterine Cancer	CCLE	DRRQLNTIT	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86TV6	Tetratricopeptide repeat protein 7B	DEG_APCC_DBOX_1	638:646	DRRQLNTIT	APC,CDC20,FZR1	0.8935	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons