DegronMD - Q86UA6(RPAIN)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A2V	TCGA-AA-A01V	COAD	TCGA	PRRSLYKLV	DEG_APCC_DBOX_1	8:16	Mutation blocking ubiquitination signal	0.6111
p.A2V	DO7822	COAD	ICGC	PRRSLYKLV	DEG_APCC_DBOX_1	8:16	Mutation blocking ubiquitination signal	0.6111
p.W21R	TCGA-CV-7254	HNSC	TCGA	PRRSLYKLV	DEG_APCC_DBOX_1	8:16	Mutation rewiring degron network	0.1944
p.W21R	DO14168	HNSC	ICGC	PRRSLYKLV	DEG_APCC_DBOX_1	8:16	Mutation rewiring degron network	0.1944
p.W21L	TCGA-CV-7254	HNSC	TCGA	PRRSLYKLV	DEG_APCC_DBOX_1	8:16	Mutation rewiring degron network	0.1944
p.W21L	DO14168	HNSC	ICGC	PRRSLYKLV	DEG_APCC_DBOX_1	8:16	Mutation rewiring degron network	0.1944
p.P8S	DO225161	BRCA	ICGC	PRRSLYKLV	DEG_APCC_DBOX_1	8:16	Mutation altering degron motif	0.5641
p.R10L	DO228978	LICA	ICGC	PRRSLYKLV	DEG_APCC_DBOX_1	8:16	Mutation altering degron motif	0.7316
p.G17V	DO229015	LICA	ICGC	PRRSLYKLV	DEG_APCC_DBOX_1	8:16	Mutation rewiring degron network	0.3056
p.K14I	SIDM01197	Colorectal Carcinoma	GDSC	PRRSLYKLV	DEG_APCC_DBOX_1	8:16	Mutation altering degron motif	0.642
p.K14I	ACH-000722	Colon/Colorectal Cancer	CCLE	PRRSLYKLV	DEG_APCC_DBOX_1	8:16	Mutation altering degron motif	0.642
p.K14I	SNU-C1	large intestine	COSMIC	PRRSLYKLV	DEG_APCC_DBOX_1	8:16	Mutation altering degron motif	0.642
p.S11F	SIDM00535	Chondrosarcoma	GDSC	PRRSLYKLV	DEG_APCC_DBOX_1	8:16	Mutation altering degron motif	0.7982
p.S11F	ACH-001519	Bone Cancer	CCLE	PRRSLYKLV	DEG_APCC_DBOX_1	8:16	Mutation altering degron motif	0.7982
p.S11F	H-EMC-SS	bone	COSMIC	PRRSLYKLV	DEG_APCC_DBOX_1	8:16	Mutation altering degron motif	0.7982
p.R9P	ACH-001701	Head and Neck Cancer	CCLE	PRRSLYKLV	DEG_APCC_DBOX_1	8:16	Mutation altering degron motif	0.7512

Kaplan plot for RPAIN in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RPAIN

UniProt ID: Q86UA6

Entrez ID: 84268

Protein name: RPA-interacting protein (hRIP)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for RPAIN in