DegronMD

Uniprot ID: Q86UA6

Source protein: RPA-interacting protein

Source gene: RPAIN

Class: DEG_APCC_DBOX_1

Location: 8:16

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.989

ASA_SCORE: 102.4

COIL: 0.6424

CONS_SCORE: 0.6248

DSS_SCORE: 0.3821

HELIX: 0.2916

FCONS_SCORE: 1.0176

RIG_SCORE: 0.7113

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A2V	TCGA-AA-A01V	COAD	TCGA	PRRSLYKLV	DEG_APCC_DBOX_1	0.6111
p.A2V	DO7822	COAD	ICGC	PRRSLYKLV	DEG_APCC_DBOX_1	0.6111
p.W21R	TCGA-CV-7254	HNSC	TCGA	PRRSLYKLV	DEG_APCC_DBOX_1	0.1944
p.W21R	DO14168	HNSC	ICGC	PRRSLYKLV	DEG_APCC_DBOX_1	0.1944
p.W21L	TCGA-CV-7254	HNSC	TCGA	PRRSLYKLV	DEG_APCC_DBOX_1	0.1944
p.W21L	DO14168	HNSC	ICGC	PRRSLYKLV	DEG_APCC_DBOX_1	0.1944
p.P8S	DO225161	BRCA	ICGC	PRRSLYKLV	DEG_APCC_DBOX_1	0.5641
p.R10L	DO228978	LICA	ICGC	PRRSLYKLV	DEG_APCC_DBOX_1	0.7316
p.G17V	DO229015	LICA	ICGC	PRRSLYKLV	DEG_APCC_DBOX_1	0.3056
p.K14I	SIDM01197	Colorectal Carcinoma	GDSC	PRRSLYKLV	DEG_APCC_DBOX_1	0.642
p.K14I	ACH-000722	Colon/Colorectal Cancer	CCLE	PRRSLYKLV	DEG_APCC_DBOX_1	0.642
p.K14I	SNU-C1	large_intestine	COSMIC	PRRSLYKLV	DEG_APCC_DBOX_1	0.642
p.S11F	SIDM00535	Chondrosarcoma	GDSC	PRRSLYKLV	DEG_APCC_DBOX_1	0.7982
p.S11F	ACH-001519	Bone Cancer	CCLE	PRRSLYKLV	DEG_APCC_DBOX_1	0.7982
p.S11F	H-EMC-SS	bone	COSMIC	PRRSLYKLV	DEG_APCC_DBOX_1	0.7982
p.R9P	ACH-001701	Head and Neck Cancer	CCLE	PRRSLYKLV	DEG_APCC_DBOX_1	0.7512

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86UA6	RPA-interacting protein	DEG_APCC_DBOX_1	8:16	PRRSLYKLV	APC,CDC20,FZR1	0.989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons