DegronMD - Q86UP0(CDH24)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I408V	TCGA-BP-4968	KIRC	TCGA	ILPHSD	LIG_APCC_ABBA_1	412:417	Mutation rewiring degron network	0.2222
p.I408V	DO16269	KIRC	ICGC	ILPHSD	LIG_APCC_ABBA_1	412:417	Mutation rewiring degron network	0.2222
p.E419K	TCGA-D8-A27V	BRCA	TCGA	ILPHSD	LIG_APCC_ABBA_1	412:417	Mutation rewiring degron network	0.2778
p.E419K	DO6048	BRCA	ICGC	ILPHSD	LIG_APCC_ABBA_1	412:417	Mutation rewiring degron network	0.2778
p.S403F	TCGA-FR-A3YO	SKCM	TCGA	ILPHSD	LIG_APCC_ABBA_1	412:417	Mutation rewiring degron network	0.0833
p.S403F	DO37419	SKCM	ICGC	ILPHSD	LIG_APCC_ABBA_1	412:417	Mutation rewiring degron network	0.0833
p.S423C	DO225005	BRCA	ICGC	ILPHSD	LIG_APCC_ABBA_1	412:417	Mutation rewiring degron network	0.1667
p.I424T	DO222821	BTCA	ICGC	ILPHSD	LIG_APCC_ABBA_1	412:417	Mutation rewiring degron network	0.1389
p.Q425K	DO228974	LICA	ICGC	ILPHSD	LIG_APCC_ABBA_1	412:417	Mutation rewiring degron network	0.1111
p.Q425L	SIDM00961	Ewing's Sarcoma	GDSC	ILPHSD	LIG_APCC_ABBA_1	412:417	Mutation rewiring degron network	0.1111
p.Q425L	SIDM00469	Pancreatic Carcinoma	GDSC	ILPHSD	LIG_APCC_ABBA_1	412:417	Mutation rewiring degron network	0.1111
p.Q425L	CADO-ES1	bone	COSMIC	ILPHSD	LIG_APCC_ABBA_1	412:417	Mutation rewiring degron network	0.1111
p.Q425L	PSN1	pancreas	COSMIC	ILPHSD	LIG_APCC_ABBA_1	412:417	Mutation rewiring degron network	0.1111
p.R409I	SIDM01103	Squamous Cell Lung Carcinoma	GDSC	ILPHSD	LIG_APCC_ABBA_1	412:417	Mutation rewiring degron network	0.25
p.R420H	SIDM00947	Glioblastoma	GDSC	ILPHSD	LIG_APCC_ABBA_1	412:417	Mutation rewiring degron network	0.25
p.R420H	ACH-000244	Brain Cancer	CCLE	ILPHSD	LIG_APCC_ABBA_1	412:417	Mutation rewiring degron network	0.25
p.R420H	DK-MG	central nervous system	COSMIC	ILPHSD	LIG_APCC_ABBA_1	412:417	Mutation rewiring degron network	0.25
p.H415N	SIDM01133	Other Solid Cancers	GDSC	ILPHSD	LIG_APCC_ABBA_1	412:417	Mutation altering degron motif	0.7423
p.H415N	ACH-002177	Lung Cancer	CCLE	ILPHSD	LIG_APCC_ABBA_1	412:417	Mutation altering degron motif	0.7423
p.H415N	NCI-H835	lung	COSMIC	ILPHSD	LIG_APCC_ABBA_1	412:417	Mutation altering degron motif	0.7423
p.P418L	SIDM00273	Glioblastoma	GDSC	ILPHSD	LIG_APCC_ABBA_1	412:417	Mutation rewiring degron network	0.3056
p.P426A	ACH-001300	Neuroblastoma	CCLE	ILPHSD	LIG_APCC_ABBA_1	412:417	Mutation rewiring degron network	0.0833

Kaplan plot for CDH24 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDH24

UniProt ID: Q86UP0

Entrez ID: 64403

Protein name: Cadherin-24

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDH24 in