DegronMD

Uniprot ID: Q86UP0

Source protein: Cadherin-24

Source gene: CDH24

Class: LIG_APCC_ABBA_1

Location: 412:417

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5238

ASA_SCORE: 49.7167

COIL: 0.485

CONS_SCORE: 0.7777

DSS_SCORE: 0.4526

HELIX: 0.0217

FCONS_SCORE: 0.9574

RIG_SCORE: 0.6873

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I408V	TCGA-BP-4968	KIRC	TCGA	ILPHSD	LIG_APCC_ABBA_1	0.2222
p.I408V	DO16269	KIRC	ICGC	ILPHSD	LIG_APCC_ABBA_1	0.2222
p.E419K	TCGA-D8-A27V	BRCA	TCGA	ILPHSD	LIG_APCC_ABBA_1	0.2778
p.E419K	DO6048	BRCA	ICGC	ILPHSD	LIG_APCC_ABBA_1	0.2778
p.S403F	TCGA-FR-A3YO	SKCM	TCGA	ILPHSD	LIG_APCC_ABBA_1	0.0833
p.S403F	DO37419	SKCM	ICGC	ILPHSD	LIG_APCC_ABBA_1	0.0833
p.S423C	DO225005	BRCA	ICGC	ILPHSD	LIG_APCC_ABBA_1	0.1667
p.I424T	DO222821	BTCA	ICGC	ILPHSD	LIG_APCC_ABBA_1	0.1389
p.Q425K	DO228974	LICA	ICGC	ILPHSD	LIG_APCC_ABBA_1	0.1111
p.Q425L	SIDM00961	Ewing's Sarcoma	GDSC	ILPHSD	LIG_APCC_ABBA_1	0.1111
p.Q425L	SIDM00469	Pancreatic Carcinoma	GDSC	ILPHSD	LIG_APCC_ABBA_1	0.1111
p.Q425L	CADO-ES1	bone	COSMIC	ILPHSD	LIG_APCC_ABBA_1	0.1111
p.Q425L	PSN1	pancreas	COSMIC	ILPHSD	LIG_APCC_ABBA_1	0.1111
p.R409I	SIDM01103	Squamous Cell Lung Carcinoma	GDSC	ILPHSD	LIG_APCC_ABBA_1	0.25
p.R420H	SIDM00947	Glioblastoma	GDSC	ILPHSD	LIG_APCC_ABBA_1	0.25
p.R420H	ACH-000244	Brain Cancer	CCLE	ILPHSD	LIG_APCC_ABBA_1	0.25
p.R420H	DK-MG	central_nervous_system	COSMIC	ILPHSD	LIG_APCC_ABBA_1	0.25
p.H415N	SIDM01133	Other Solid Cancers	GDSC	ILPHSD	LIG_APCC_ABBA_1	0.7423
p.H415N	ACH-002177	Lung Cancer	CCLE	ILPHSD	LIG_APCC_ABBA_1	0.7423
p.H415N	NCI-H835	lung	COSMIC	ILPHSD	LIG_APCC_ABBA_1	0.7423
p.P418L	SIDM00273	Glioblastoma	GDSC	ILPHSD	LIG_APCC_ABBA_1	0.3056
p.P426A	ACH-001300	Neuroblastoma	CCLE	ILPHSD	LIG_APCC_ABBA_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86UP0	Cadherin-24	LIG_APCC_ABBA_1	412:417	ILPHSD	APC,CDC20,FZR1	0.5238	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons