DegronMD - Q86US8(SMG6)

SMG6

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N31K	TCGA-C8-A1HM	BRCA	TCGA	LRGILATLA	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.1111
p.N31K	DO3904	BRCA	ICGC	LRGILATLA	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.1111
p.R30H	DO10332	COAD	ICGC	LRGILATLA	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.1389
p.R30H	DO47819	STAD	ICGC	LRGILATLA	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.1389
p.Q33K	DO228948	LICA	ICGC	LRGILATLA	DEG_APCC_DBOX_1	15:23	Mutation substituting flanking lysine	0.1667
p.L19M	DO228948	LICA	ICGC	LRGILATLA	DEG_APCC_DBOX_1	15:23	Mutation altering degron motif	0.711
p.Q33P	DO29890	OV	ICGC	LRGILATLA	DEG_APCC_DBOX_1	15:23	Mutation substituting flanking lysine	0.1667
p.S11F	DO229211	THCA	ICGC	LRGILATLA	DEG_APCC_DBOX_1	15:23	Mutation blocking phosphorylation signal	0.6667
p.M32T	SIDM00496	Thyroid Gland Carcinoma	GDSC	LRGILATLA	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.0833
p.M32T	ACH-001350	Thyroid Cancer	CCLE	LRGILATLA	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.0833
p.M32T	HTC-C3	thyroid	COSMIC	LRGILATLA	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.0833
p.I18N	ACH-000982	Colon/Colorectal Cancer	CCLE	LRGILATLA	DEG_APCC_DBOX_1	15:23	Mutation altering degron motif	0.6169
p.I18N	ACH-001345	Colon/Colorectal Cancer	CCLE	LRGILATLA	DEG_APCC_DBOX_1	15:23	Mutation altering degron motif	0.6169
p.R16H	ACH-000995	Leukemia	CCLE	LRGILATLA	DEG_APCC_DBOX_1	15:23	Mutation altering degron motif	0.8244

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*NOTE: the Kaplan plots were collected from OncoLnc