DegronMD

Uniprot ID: Q86US8

Source protein: Telomerase-binding protein EST1A

Source gene: SMG6

Class: DEG_APCC_DBOX_1

Location: 15:23

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9368

ASA_SCORE: 53.5444

COIL: 0.2636

CONS_SCORE: 0.2659

DSS_SCORE: 0.4048

HELIX: 0.7282

FCONS_SCORE: 1.0176

RIG_SCORE: 0.7574

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N31K	TCGA-C8-A1HM	BRCA	TCGA	LRGILATLA	DEG_APCC_DBOX_1	0.1111
p.N31K	DO3904	BRCA	ICGC	LRGILATLA	DEG_APCC_DBOX_1	0.1111
p.R30H	DO10332	COAD	ICGC	LRGILATLA	DEG_APCC_DBOX_1	0.1389
p.R30H	DO47819	STAD	ICGC	LRGILATLA	DEG_APCC_DBOX_1	0.1389
p.Q33K	DO228948	LICA	ICGC	LRGILATLA	DEG_APCC_DBOX_1	0.1667
p.L19M	DO228948	LICA	ICGC	LRGILATLA	DEG_APCC_DBOX_1	0.711
p.Q33P	DO29890	OV	ICGC	LRGILATLA	DEG_APCC_DBOX_1	0.1667
p.S11F	DO229211	THCA	ICGC	LRGILATLA	DEG_APCC_DBOX_1	0.6667
p.M32T	SIDM00496	Thyroid Gland Carcinoma	GDSC	LRGILATLA	DEG_APCC_DBOX_1	0.0833
p.M32T	ACH-001350	Thyroid Cancer	CCLE	LRGILATLA	DEG_APCC_DBOX_1	0.0833
p.M32T	HTC-C3	thyroid	COSMIC	LRGILATLA	DEG_APCC_DBOX_1	0.0833
p.I18N	ACH-000982	Colon/Colorectal Cancer	CCLE	LRGILATLA	DEG_APCC_DBOX_1	0.6169
p.I18N	ACH-001345	Colon/Colorectal Cancer	CCLE	LRGILATLA	DEG_APCC_DBOX_1	0.6169
p.R16H	ACH-000995	Leukemia	CCLE	LRGILATLA	DEG_APCC_DBOX_1	0.8244

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86US8	Telomerase-binding protein EST1A	DEG_APCC_DBOX_1	15:23	LRGILATLA	APC,CDC20,FZR1	0.9368	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons