DegronMD - Q86UT5(PDZD3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G457E	TCGA-60-2726	LUSC	TCGA	SLEDTSVPSV	DEG_COP1_1	452:461	Mutation altering degron motif	0.7199
p.G457E	DO27484	LUSC	ICGC	SLEDTSVPSV	DEG_COP1_1	452:461	Mutation altering degron motif	0.7199
p.G452R	TCGA-ER-A198	SKCM	TCGA	SLEDTSVPSV	DEG_COP1_1	452:461	Mutation altering degron motif	0.7568
p.R463M	TCGA-IN-A6RR	STAD	TCGA	SLEDTSVPSV	DEG_COP1_1	452:461	Mutation rewiring degron network	0.2778
p.L463P	DO222755	COCA	ICGC	SLEDTSVPSV	DEG_COP1_1	452:461	Mutation rewiring degron network	0.2778
p.V458M	DO234250	ESAD	ICGC	SLEDTSVPSV	DEG_COP1_1	452:461	Mutation altering degron motif	0.7208
p.A443T	DO234336	ESAD	ICGC	SLEDTSVPSV	DEG_COP1_1	452:461	Mutation rewiring degron network	0.0833
p.L470P	DO45299	LIRI	ICGC	SLEDTSVPSV	DEG_COP1_1	452:461	Mutation rewiring degron network	0.0833
p.G452E	DO229502	SKCA	ICGC	SLEDTSVPSV	DEG_COP1_1	452:461	Mutation altering degron motif	0.7199
p.R466Q	DO41379	UCEC	ICGC	SLEDTSVPSV	DEG_COP1_1	452:461	Mutation rewiring degron network	0.1944
p.D460N	SIDM01263	T-Lymphoblastic Leukemia	GDSC	SLEDTSVPSV	DEG_COP1_1	452:461	Mutation altering degron motif	0.6932
p.C462G	ACH-000858	Lung Cancer	CCLE	SLEDTSVPSV	DEG_COP1_1	452:461	Mutation rewiring degron network	0.3056
p.C462G	KNS-62	lung	COSMIC	SLEDTSVPSV	DEG_COP1_1	452:461	Mutation rewiring degron network	0.3056
p.C461G	KNS-62	lung	COSMIC	SLEDTSVPSV	DEG_COP1_1	452:461	Mutation altering degron motif	0.76
p.F469L	NCI-H2227	lung	COSMIC	SLEDTSVPSV	DEG_COP1_1	452:461	Mutation rewiring degron network	0.1111
p.Y471H	GP5d	large intestine	COSMIC	SLEDTSVPSV	DEG_COP1_1	452:461	Mutation rewiring degron network	0.0556

Kaplan plot for PDZD3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PDZD3

UniProt ID: Q86UT5

Entrez ID: 79849

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PDZD3 in