DegronMD

Uniprot ID: Q86UT5

Source protein: Na

Source gene: PDZD3

Class: DEG_COP1_1

Location: 452:461

E3 ligase: COP1

DEGRON score: 0.5161

ASA_SCORE: 82.6

COIL: 0.8572

CONS_SCORE: 0.6471

DSS_SCORE: 0.5361

HELIX: 0.0982

FCONS_SCORE: 0.9857

RIG_SCORE: 0.6909

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G457E	TCGA-60-2726	LUSC	TCGA	SLEDTSVPSV	DEG_COP1_1	0.7199
p.G457E	DO27484	LUSC	ICGC	SLEDTSVPSV	DEG_COP1_1	0.7199
p.G452R	TCGA-ER-A198	SKCM	TCGA	SLEDTSVPSV	DEG_COP1_1	0.7568
p.R463M	TCGA-IN-A6RR	STAD	TCGA	SLEDTSVPSV	DEG_COP1_1	0.2778
p.L463P	DO222755	COCA	ICGC	SLEDTSVPSV	DEG_COP1_1	0.2778
p.V458M	DO234250	ESAD	ICGC	SLEDTSVPSV	DEG_COP1_1	0.7208
p.A443T	DO234336	ESAD	ICGC	SLEDTSVPSV	DEG_COP1_1	0.0833
p.L470P	DO45299	LIRI	ICGC	SLEDTSVPSV	DEG_COP1_1	0.0833
p.G452E	DO229502	SKCA	ICGC	SLEDTSVPSV	DEG_COP1_1	0.7199
p.R466Q	DO41379	UCEC	ICGC	SLEDTSVPSV	DEG_COP1_1	0.1944
p.D460N	SIDM01263	T-Lymphoblastic Leukemia	GDSC	SLEDTSVPSV	DEG_COP1_1	0.6932
p.C462G	ACH-000858	Lung Cancer	CCLE	SLEDTSVPSV	DEG_COP1_1	0.3056
p.C462G	KNS-62	lung	COSMIC	SLEDTSVPSV	DEG_COP1_1	0.3056
p.C461G	KNS-62	lung	COSMIC	SLEDTSVPSV	DEG_COP1_1	0.76
p.F469L	NCI-H2227	lung	COSMIC	SLEDTSVPSV	DEG_COP1_1	0.1111
p.Y471H	GP5d	large_intestine	COSMIC	SLEDTSVPSV	DEG_COP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86UT5	Na	DEG_COP1_1	452:461	SLEDTSVPSV	COP1	0.5161	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons