DegronMD - Q86UU9(TAC4)

TAC4

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E108K	TCGA-34-8454	LUSC	TCGA	KRSLFTE	LIG_APCC_ABBAyCdc20_2	97:103	Mutation rewiring degron network	0.1944
p.L100M	TCGA-50-5066	LUAD	TCGA	KRSLFTE	LIG_APCC_ABBAyCdc20_2	97:103	Mutation altering degron motif	0.5999
p.R98I	TCGA-AA-3977	COAD	TCGA	KRSLFTE	LIG_APCC_ABBAyCdc20_2	97:103	Mutation altering degron motif	0.6991
p.A109T	TCGA-EY-A1GK	UCEC	TCGA	KRSLFTE	LIG_APCC_ABBAyCdc20_2	97:103	Mutation rewiring degron network	0.1667
p.H89Y	TCGA-O2-A52N	LUSC	TCGA	KRSLFTE	LIG_APCC_ABBAyCdc20_2	97:103	Mutation rewiring degron network	0.1111
p.R92I	DO8730	COAD	ICGC	KRSLFTE	LIG_APCC_ABBAyCdc20_2	97:103	Mutation rewiring degron network	0.1944
p.F95L	DO229006	LICA	ICGC	KRSLFTE	LIG_APCC_ABBAyCdc20_2	97:103	Mutation rewiring degron network	0.2778
p.L94M	DO25040	LUAD	ICGC	KRSLFTE	LIG_APCC_ABBAyCdc20_2	97:103	Mutation rewiring degron network	0.25
p.E102K	DO50094	LUSC	ICGC	KRSLFTE	LIG_APCC_ABBAyCdc20_2	97:103	Mutation altering degron motif	0.7022
p.A103T	DO42985	UCEC	ICGC	KRSLFTE	LIG_APCC_ABBAyCdc20_2	97:103	Mutation altering degron motif	0.7139
p.T90M	SIDM00413	B-Cell Non-Hodgkin's Lymphoma	GDSC	KRSLFTE	LIG_APCC_ABBAyCdc20_2	97:103	Mutation rewiring degron network	0.1389
p.T90M	ACH-000534	Lymphoma	CCLE	KRSLFTE	LIG_APCC_ABBAyCdc20_2	97:103	Mutation rewiring degron network	0.1389
p.T90M	WSU-DLCL2	haematopoietic and lymphoid tissue	COSMIC	KRSLFTE	LIG_APCC_ABBAyCdc20_2	97:103	Mutation rewiring degron network	0.1389

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*NOTE: the Kaplan plots were collected from OncoLnc