DegronMD

Uniprot ID: Q86UU9

Source protein: Tachykinin-4

Source gene: TAC4

Class: LIG_APCC_ABBAyCdc20_2

Location: 97:103

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5426

ASA_SCORE: 95.5

COIL: 0.644

CONS_SCORE: 0.6888

DSS_SCORE: 0.5004

HELIX: 0.0906

FCONS_SCORE: 1.1351

RIG_SCORE: 0.7356

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E108K	TCGA-34-8454	LUSC	TCGA	KRSLFTE	LIG_APCC_ABBAyCdc20_2	0.1944
p.L100M	TCGA-50-5066	LUAD	TCGA	KRSLFTE	LIG_APCC_ABBAyCdc20_2	0.5999
p.R98I	TCGA-AA-3977	COAD	TCGA	KRSLFTE	LIG_APCC_ABBAyCdc20_2	0.6991
p.A109T	TCGA-EY-A1GK	UCEC	TCGA	KRSLFTE	LIG_APCC_ABBAyCdc20_2	0.1667
p.H89Y	TCGA-O2-A52N	LUSC	TCGA	KRSLFTE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R92I	DO8730	COAD	ICGC	KRSLFTE	LIG_APCC_ABBAyCdc20_2	0.1944
p.F95L	DO229006	LICA	ICGC	KRSLFTE	LIG_APCC_ABBAyCdc20_2	0.2778
p.L94M	DO25040	LUAD	ICGC	KRSLFTE	LIG_APCC_ABBAyCdc20_2	0.25
p.E102K	DO50094	LUSC	ICGC	KRSLFTE	LIG_APCC_ABBAyCdc20_2	0.7022
p.A103T	DO42985	UCEC	ICGC	KRSLFTE	LIG_APCC_ABBAyCdc20_2	0.7139
p.T90M	SIDM00413	B-Cell Non-Hodgkin's Lymphoma	GDSC	KRSLFTE	LIG_APCC_ABBAyCdc20_2	0.1389
p.T90M	ACH-000534	Lymphoma	CCLE	KRSLFTE	LIG_APCC_ABBAyCdc20_2	0.1389
p.T90M	WSU-DLCL2	haematopoietic_and_lymphoid_tissue	COSMIC	KRSLFTE	LIG_APCC_ABBAyCdc20_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86UU9	Tachykinin-4	LIG_APCC_ABBAyCdc20_2	97:103	KRSLFTE	APC,CDC20,FZR1	0.5426	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons