DegronMD - Q86VD1(MORC1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H588N	TCGA-51-4079	LUSC	TCGA	HKENT	DEG_APCC_KENBOX_2	588:592	Mutation altering degron motif	0.6312
p.H588N	DO26437	LUSC	ICGC	HKENT	DEG_APCC_KENBOX_2	588:592	Mutation altering degron motif	0.6312
p.K596I	TCGA-FD-A5C0	BLCA	TCGA	HKENT	DEG_APCC_KENBOX_2	588:592	Mutation substituting flanking lysine	0.3333
p.K596I	DO44046	BLCA	ICGC	HKENT	DEG_APCC_KENBOX_2	588:592	Mutation substituting flanking lysine	0.3333
p.S581F	TCGA-FS-A1ZK	SKCM	TCGA	HKENT	DEG_APCC_KENBOX_2	588:592	Mutation rewiring degron network	0.1389
p.S581F	DO220852	MELA	ICGC	HKENT	DEG_APCC_KENBOX_2	588:592	Mutation rewiring degron network	0.1389
p.S581F	DO37474	SKCM	ICGC	HKENT	DEG_APCC_KENBOX_2	588:592	Mutation rewiring degron network	0.1389
p.G601V	DO231124	LUSC	ICGC	HKENT	DEG_APCC_KENBOX_2	588:592	Mutation rewiring degron network	0.0833
p.L584I	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	HKENT	DEG_APCC_KENBOX_2	588:592	Mutation rewiring degron network	0.2222
p.L584I	ACH-000843	Lung Cancer	CCLE	HKENT	DEG_APCC_KENBOX_2	588:592	Mutation rewiring degron network	0.2222
p.L584I	HARA	lung	COSMIC	HKENT	DEG_APCC_KENBOX_2	588:592	Mutation rewiring degron network	0.2222
p.S596G	ACH-000943	Colon/Colorectal Cancer	CCLE	HKENT	DEG_APCC_KENBOX_2	588:592	Mutation substituting flanking lysine	0.3333
p.S596G	RKO	large intestine	COSMIC	HKENT	DEG_APCC_KENBOX_2	588:592	Mutation substituting flanking lysine	0.3333
p.D582E	ACH-001618	Leukemia	CCLE	HKENT	DEG_APCC_KENBOX_2	588:592	Mutation rewiring degron network	0.1667
p.A595V	M059J	central nervous system	COSMIC	HKENT	DEG_APCC_KENBOX_2	588:592	Mutation rewiring degron network	0.25

Kaplan plot for MORC1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MORC1

UniProt ID: Q86VD1

Entrez ID: 27136

Protein name: MORC family CW-type zinc finger protein 1 (Cancer/testis antigen 33) (CT33)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MORC1 in