DegronMD

Uniprot ID: Q86VD1

Source protein: MORC family CW-type zinc finger protein 1

Source gene: MORC1

Class: DEG_APCC_KENBOX_2

Location: 588:592

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7009

ASA_SCORE: 111.92

COIL: 0.6582

CONS_SCORE: 0.374

DSS_SCORE: 0.3911

HELIX: 0.3286

FCONS_SCORE: 1.008

RIG_SCORE: 0.7492

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H588N	TCGA-51-4079	LUSC	TCGA	HKENT	DEG_APCC_KENBOX_2	0.6312
p.H588N	DO26437	LUSC	ICGC	HKENT	DEG_APCC_KENBOX_2	0.6312
p.K596I	TCGA-FD-A5C0	BLCA	TCGA	HKENT	DEG_APCC_KENBOX_2	0.3333
p.K596I	DO44046	BLCA	ICGC	HKENT	DEG_APCC_KENBOX_2	0.3333
p.S581F	TCGA-FS-A1ZK	SKCM	TCGA	HKENT	DEG_APCC_KENBOX_2	0.1389
p.S581F	DO220852	MELA	ICGC	HKENT	DEG_APCC_KENBOX_2	0.1389
p.S581F	DO37474	SKCM	ICGC	HKENT	DEG_APCC_KENBOX_2	0.1389
p.G601V	DO231124	LUSC	ICGC	HKENT	DEG_APCC_KENBOX_2	0.0833
p.L584I	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	HKENT	DEG_APCC_KENBOX_2	0.2222
p.L584I	ACH-000843	Lung Cancer	CCLE	HKENT	DEG_APCC_KENBOX_2	0.2222
p.L584I	HARA	lung	COSMIC	HKENT	DEG_APCC_KENBOX_2	0.2222
p.S596G	ACH-000943	Colon/Colorectal Cancer	CCLE	HKENT	DEG_APCC_KENBOX_2	0.3333
p.S596G	RKO	large_intestine	COSMIC	HKENT	DEG_APCC_KENBOX_2	0.3333
p.D582E	ACH-001618	Leukemia	CCLE	HKENT	DEG_APCC_KENBOX_2	0.1667
p.A595V	M059J	central_nervous_system	COSMIC	HKENT	DEG_APCC_KENBOX_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P05546	Heparin cofactor 2	DEG_APCC_KENBOX_2	60:64	HKENT	APC,CDC20,FZR1	0.6429	More...
Q86VD1	MORC family CW-type zinc finger protein 1	DEG_APCC_KENBOX_2	588:592	HKENT	APC,CDC20,FZR1	0.7009	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons