DegronMD

Uniprot ID: P05546

Source protein: Heparin cofactor 2

Source gene: SERPIND1

Class: DEG_APCC_KENBOX_2

Location: 60:64

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6429

ASA_SCORE: 95.44

COIL: 0.7808

CONS_SCORE: 0.2899

DSS_SCORE: 0.4538

HELIX: 0.1354

FCONS_SCORE: 0.9682

RIG_SCORE: 0.7206

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D68E	TCGA-18-3409	LUSC	TCGA	HKENT	DEG_APCC_KENBOX_2	0.2222
p.D68E	DO26444	LUSC	ICGC	HKENT	DEG_APCC_KENBOX_2	0.2222
p.E62K	TCGA-D3-A8GM	SKCM	TCGA	HKENT	DEG_APCC_KENBOX_2	0.7022
p.E62K	TCGA-Z2-AA3V	SKCM	TCGA	HKENT	DEG_APCC_KENBOX_2	0.7022
p.E62K	DO50288	SKCM	ICGC	HKENT	DEG_APCC_KENBOX_2	0.7022
p.E62K	DO51303	SKCM	ICGC	HKENT	DEG_APCC_KENBOX_2	0.7022
p.E72Q	TCGA-DK-A3IS	BLCA	TCGA	HKENT	DEG_APCC_KENBOX_2	0.1111
p.E72Q	DO566	BLCA	ICGC	HKENT	DEG_APCC_KENBOX_2	0.1111
p.N67D	TCGA-EY-A1G8	UCEC	TCGA	HKENT	DEG_APCC_KENBOX_2	0.25
p.N67D	DO43578	UCEC	ICGC	HKENT	DEG_APCC_KENBOX_2	0.25
p.E74K	TCGA-YG-AA3N	SKCM	TCGA	HKENT	DEG_APCC_KENBOX_2	0.0556
p.E74K	DO51298	SKCM	ICGC	HKENT	DEG_APCC_KENBOX_2	0.0556
p.G73E	DO220857	MELA	ICGC	HKENT	DEG_APCC_KENBOX_2	0.0833
p.D68N	DO229459	SKCA	ICGC	HKENT	DEG_APCC_KENBOX_2	0.2222
p.P53A	ACH-001057	Lymphoma	CCLE	HKENT	DEG_APCC_KENBOX_2	0.1389
p.L55R	ACH-001991	Primary	CCLE	HKENT	DEG_APCC_KENBOX_2	0.1944
p.V65I	ACH-002647	Gastric Cancer	CCLE	HKENT	DEG_APCC_KENBOX_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P05546	Heparin cofactor 2	DEG_APCC_KENBOX_2	60:64	HKENT	APC,CDC20,FZR1	0.6429	More...
Q86VD1	MORC family CW-type zinc finger protein 1	DEG_APCC_KENBOX_2	588:592	HKENT	APC,CDC20,FZR1	0.7009	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons