DegronMD - P05546(SERPIND1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D68E	TCGA-18-3409	LUSC	TCGA	HKENT	DEG_APCC_KENBOX_2	60:64	Mutation rewiring degron network	0.2222
p.D68E	DO26444	LUSC	ICGC	HKENT	DEG_APCC_KENBOX_2	60:64	Mutation rewiring degron network	0.2222
p.R483H	TCGA-43-A474	LUSC	TCGA	DRPFLFLIY	DEG_APCC_DBOX_1	472:480	Mutation rewiring degron network	0.25
p.R483H	DO233272	GACA	ICGC	DRPFLFLIY	DEG_APCC_DBOX_1	472:480	Mutation rewiring degron network	0.25
p.R483H	DO45490	LUSC	ICGC	DRPFLFLIY	DEG_APCC_DBOX_1	472:480	Mutation rewiring degron network	0.25
p.R483H	SIDM00933	Breast Carcinoma	GDSC	DRPFLFLIY	DEG_APCC_DBOX_1	472:480	Mutation rewiring degron network	0.25
p.R483H	ACH-000856	Breast Cancer	CCLE	DRPFLFLIY	DEG_APCC_DBOX_1	472:480	Mutation rewiring degron network	0.25
p.R483H	ACH-002287	Colon/Colorectal Cancer	CCLE	DRPFLFLIY	DEG_APCC_DBOX_1	472:480	Mutation rewiring degron network	0.25
p.R473H	TCGA-AX-A06F	UCEC	TCGA	DRPFLFLIY	DEG_APCC_DBOX_1	472:480	Mutation altering degron motif	0.8244
p.R473H	TCGA-AX-A3FT	UCEC	TCGA	DRPFLFLIY	DEG_APCC_DBOX_1	472:480	Mutation altering degron motif	0.8244
p.R473H	DO40801	UCEC	ICGC	DRPFLFLIY	DEG_APCC_DBOX_1	472:480	Mutation altering degron motif	0.8244
p.R473H	DO41752	UCEC	ICGC	DRPFLFLIY	DEG_APCC_DBOX_1	472:480	Mutation altering degron motif	0.8244
p.P474S	TCGA-AX-A3FT	UCEC	TCGA	DRPFLFLIY	DEG_APCC_DBOX_1	472:480	Mutation altering degron motif	0.5641
p.P474S	DO40801	UCEC	ICGC	DRPFLFLIY	DEG_APCC_DBOX_1	472:480	Mutation altering degron motif	0.5641
p.E62K	TCGA-D3-A8GM	SKCM	TCGA	HKENT	DEG_APCC_KENBOX_2	60:64	Mutation altering degron motif	0.7022
p.E62K	TCGA-Z2-AA3V	SKCM	TCGA	HKENT	DEG_APCC_KENBOX_2	60:64	Mutation altering degron motif	0.7022
p.E62K	DO50288	SKCM	ICGC	HKENT	DEG_APCC_KENBOX_2	60:64	Mutation altering degron motif	0.7022
p.E62K	DO51303	SKCM	ICGC	HKENT	DEG_APCC_KENBOX_2	60:64	Mutation altering degron motif	0.7022
p.E72Q	TCGA-DK-A3IS	BLCA	TCGA	HKENT	DEG_APCC_KENBOX_2	60:64	Mutation rewiring degron network	0.1111
p.E72Q	DO566	BLCA	ICGC	HKENT	DEG_APCC_KENBOX_2	60:64	Mutation rewiring degron network	0.1111
p.F477L	TCGA-EJ-A46D	PRAD	TCGA	DRPFLFLIY	DEG_APCC_DBOX_1	472:480	Mutation altering degron motif	0.587
p.F477L	DO48565	PRAD	ICGC	DRPFLFLIY	DEG_APCC_DBOX_1	472:480	Mutation altering degron motif	0.587
p.P474L	TCGA-EO-A3KX	UCEC	TCGA	DRPFLFLIY	DEG_APCC_DBOX_1	472:480	Mutation altering degron motif	0.6471
p.P474L	DO219774	UCEC	ICGC	DRPFLFLIY	DEG_APCC_DBOX_1	472:480	Mutation altering degron motif	0.6471
p.P474L	SIDM00007	Other Solid Cancers	GDSC	DRPFLFLIY	DEG_APCC_DBOX_1	472:480	Mutation altering degron motif	0.6471
p.P474L	ACH-001550	Skin Cancer	CCLE	DRPFLFLIY	DEG_APCC_DBOX_1	472:480	Mutation altering degron motif	0.6471
p.P474L	MCC13	skin	COSMIC	DRPFLFLIY	DEG_APCC_DBOX_1	472:480	Mutation altering degron motif	0.6471
p.L488V	TCGA-ER-A19T	SKCM	TCGA	DRPFLFLIY	DEG_APCC_DBOX_1	472:480	Mutation rewiring degron network	0.1111
p.L488V	DO51251	SKCM	ICGC	DRPFLFLIY	DEG_APCC_DBOX_1	472:480	Mutation rewiring degron network	0.1111
p.N67D	TCGA-EY-A1G8	UCEC	TCGA	HKENT	DEG_APCC_KENBOX_2	60:64	Mutation rewiring degron network	0.25
p.N67D	DO43578	UCEC	ICGC	HKENT	DEG_APCC_KENBOX_2	60:64	Mutation rewiring degron network	0.25
p.R473C	TCGA-FI-A2D0	UCEC	TCGA	DRPFLFLIY	DEG_APCC_DBOX_1	472:480	Mutation altering degron motif	0.8301
p.R473C	DO43891	UCEC	ICGC	DRPFLFLIY	DEG_APCC_DBOX_1	472:480	Mutation altering degron motif	0.8301
p.E74K	TCGA-YG-AA3N	SKCM	TCGA	HKENT	DEG_APCC_KENBOX_2	60:64	Mutation rewiring degron network	0.0556
p.E74K	DO51298	SKCM	ICGC	HKENT	DEG_APCC_KENBOX_2	60:64	Mutation rewiring degron network	0.0556
p.R473L	DO229025	LICA	ICGC	DRPFLFLIY	DEG_APCC_DBOX_1	472:480	Mutation altering degron motif	0.8428
p.V471F	DO229037	LICA	ICGC	DRPFLFLIY	DEG_APCC_DBOX_1	472:480	Mutation rewiring degron network	0.3056
p.G73E	DO220857	MELA	ICGC	HKENT	DEG_APCC_KENBOX_2	60:64	Mutation rewiring degron network	0.0833
p.D68N	DO229459	SKCA	ICGC	HKENT	DEG_APCC_KENBOX_2	60:64	Mutation rewiring degron network	0.2222
p.P53A	ACH-001057	Lymphoma	CCLE	HKENT	DEG_APCC_KENBOX_2	60:64	Mutation rewiring degron network	0.1389
p.L55R	ACH-001991	Primary	CCLE	HKENT	DEG_APCC_KENBOX_2	60:64	Mutation rewiring degron network	0.1944
p.V65I	ACH-002647	Gastric Cancer	CCLE	HKENT	DEG_APCC_KENBOX_2	60:64	Mutation rewiring degron network	0.3056

Kaplan plot for SERPIND1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SERPIND1

UniProt ID: P05546

Entrez ID: 3053

Protein name: Heparin cofactor 2 (Heparin cofactor II) (HC-II) (Protease inhibitor leuserpin-2) (HLS2) (Serpin D1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SERPIND1 in