DegronMD

Uniprot ID: P05546

Source protein: Heparin cofactor 2

Source gene: SERPIND1

Class: DEG_APCC_DBOX_1

Location: 472:480

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5198

ASA_SCORE: 21.4

COIL: 0.3117

CONS_SCORE: 0.6686

DSS_SCORE: 0.0283

HELIX: 0.0017

FCONS_SCORE: 1.2663

RIG_SCORE: 0.9742

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R483H	TCGA-43-A474	LUSC	TCGA	DRPFLFLIY	DEG_APCC_DBOX_1	0.25
p.R483H	DO233272	GACA	ICGC	DRPFLFLIY	DEG_APCC_DBOX_1	0.25
p.R483H	DO45490	LUSC	ICGC	DRPFLFLIY	DEG_APCC_DBOX_1	0.25
p.R483H	SIDM00933	Breast Carcinoma	GDSC	DRPFLFLIY	DEG_APCC_DBOX_1	0.25
p.R483H	ACH-000856	Breast Cancer	CCLE	DRPFLFLIY	DEG_APCC_DBOX_1	0.25
p.R483H	ACH-002287	Colon/Colorectal Cancer	CCLE	DRPFLFLIY	DEG_APCC_DBOX_1	0.25
p.R473H	TCGA-AX-A06F	UCEC	TCGA	DRPFLFLIY	DEG_APCC_DBOX_1	0.8244
p.R473H	TCGA-AX-A3FT	UCEC	TCGA	DRPFLFLIY	DEG_APCC_DBOX_1	0.8244
p.R473H	DO40801	UCEC	ICGC	DRPFLFLIY	DEG_APCC_DBOX_1	0.8244
p.R473H	DO41752	UCEC	ICGC	DRPFLFLIY	DEG_APCC_DBOX_1	0.8244
p.P474S	TCGA-AX-A3FT	UCEC	TCGA	DRPFLFLIY	DEG_APCC_DBOX_1	0.5641
p.P474S	DO40801	UCEC	ICGC	DRPFLFLIY	DEG_APCC_DBOX_1	0.5641
p.F477L	TCGA-EJ-A46D	PRAD	TCGA	DRPFLFLIY	DEG_APCC_DBOX_1	0.587
p.F477L	DO48565	PRAD	ICGC	DRPFLFLIY	DEG_APCC_DBOX_1	0.587
p.P474L	TCGA-EO-A3KX	UCEC	TCGA	DRPFLFLIY	DEG_APCC_DBOX_1	0.6471
p.P474L	DO219774	UCEC	ICGC	DRPFLFLIY	DEG_APCC_DBOX_1	0.6471
p.P474L	SIDM00007	Other Solid Cancers	GDSC	DRPFLFLIY	DEG_APCC_DBOX_1	0.6471
p.P474L	ACH-001550	Skin Cancer	CCLE	DRPFLFLIY	DEG_APCC_DBOX_1	0.6471
p.P474L	MCC13	skin	COSMIC	DRPFLFLIY	DEG_APCC_DBOX_1	0.6471
p.L488V	TCGA-ER-A19T	SKCM	TCGA	DRPFLFLIY	DEG_APCC_DBOX_1	0.1111
p.L488V	DO51251	SKCM	ICGC	DRPFLFLIY	DEG_APCC_DBOX_1	0.1111
p.R473C	TCGA-FI-A2D0	UCEC	TCGA	DRPFLFLIY	DEG_APCC_DBOX_1	0.8301
p.R473C	DO43891	UCEC	ICGC	DRPFLFLIY	DEG_APCC_DBOX_1	0.8301
p.R473L	DO229025	LICA	ICGC	DRPFLFLIY	DEG_APCC_DBOX_1	0.8428
p.V471F	DO229037	LICA	ICGC	DRPFLFLIY	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P05546	Heparin cofactor 2	DEG_APCC_DBOX_1	472:480	DRPFLFLIY	APC,CDC20,FZR1	0.5198	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons