DegronMD - Q86VW1(SLC22A16)

SLC22A16

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E566D	TCGA-A5-A0G2	UCEC	TCGA	ITPRDS	DEG_SCF_FBW7_1	568:573	Mutation rewiring degron network	0.2778
p.E566D	DO41235	UCEC	ICGC	ITPRDS	DEG_SCF_FBW7_1	568:573	Mutation rewiring degron network	0.2778
p.T565M	TCGA-CM-6171	COAD	TCGA	ITPRDS	DEG_SCF_FBW7_1	568:573	Mutation rewiring degron network	0.25
p.T565M	DO8151	COAD	ICGC	ITPRDS	DEG_SCF_FBW7_1	568:573	Mutation rewiring degron network	0.25
p.T565M	DO230312	COCA	ICGC	ITPRDS	DEG_SCF_FBW7_1	568:573	Mutation rewiring degron network	0.25
p.A567G	TCGA-DJ-A3UO	THCA	TCGA	ITPRDS	DEG_SCF_FBW7_1	568:573	Mutation rewiring degron network	0.3056
p.A567G	DO38950	THCA	ICGC	ITPRDS	DEG_SCF_FBW7_1	568:573	Mutation rewiring degron network	0.3056
p.A567V	TCGA-VQ-A94R	STAD	TCGA	ITPRDS	DEG_SCF_FBW7_1	568:573	Mutation rewiring degron network	0.3056
p.A567V	DO222372	STAD	ICGC	ITPRDS	DEG_SCF_FBW7_1	568:573	Mutation rewiring degron network	0.3056
p.R571S	TCGA-W3-A828	SKCM	TCGA	ITPRDS	DEG_SCF_FBW7_1	568:573	Mutation altering degron motif	0.6316
p.R571S	DO51273	SKCM	ICGC	ITPRDS	DEG_SCF_FBW7_1	568:573	Mutation altering degron motif	0.6316
p.E563K	DO222908	MELA	ICGC	ITPRDS	DEG_SCF_FBW7_1	568:573	Mutation rewiring degron network	0.1944
p.G574D	SIDM00340	Plasma Cell Myeloma	GDSC	ITPRDS	DEG_SCF_FBW7_1	568:573	Mutation rewiring degron network	0.3056
p.G574D	ACH-000204	Myeloma	CCLE	ITPRDS	DEG_SCF_FBW7_1	568:573	Mutation rewiring degron network	0.3056
p.G574D	LP-1	haematopoietic and lymphoid tissue	COSMIC	ITPRDS	DEG_SCF_FBW7_1	568:573	Mutation rewiring degron network	0.3056

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*NOTE: the Kaplan plots were collected from OncoLnc