DegronMD

Uniprot ID: Q86VW1

Source protein: Solute carrier family 22 member 16

Source gene: SLC22A16

Class: DEG_SCF_FBW7_1

Location: 568:573

E3 ligase: FBXW7

DEGRON score: 0.8613

ASA_SCORE: 104.05

COIL: 0.9328

CONS_SCORE: 0.2413

DSS_SCORE: 0.7684

HELIX: 0.0485

FCONS_SCORE: 0.955

RIG_SCORE: 0.7125

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E566D	TCGA-A5-A0G2	UCEC	TCGA	ITPRDS	DEG_SCF_FBW7_1	0.2778
p.E566D	DO41235	UCEC	ICGC	ITPRDS	DEG_SCF_FBW7_1	0.2778
p.T565M	TCGA-CM-6171	COAD	TCGA	ITPRDS	DEG_SCF_FBW7_1	0.25
p.T565M	DO8151	COAD	ICGC	ITPRDS	DEG_SCF_FBW7_1	0.25
p.T565M	DO230312	COCA	ICGC	ITPRDS	DEG_SCF_FBW7_1	0.25
p.A567G	TCGA-DJ-A3UO	THCA	TCGA	ITPRDS	DEG_SCF_FBW7_1	0.3056
p.A567G	DO38950	THCA	ICGC	ITPRDS	DEG_SCF_FBW7_1	0.3056
p.A567V	TCGA-VQ-A94R	STAD	TCGA	ITPRDS	DEG_SCF_FBW7_1	0.3056
p.A567V	DO222372	STAD	ICGC	ITPRDS	DEG_SCF_FBW7_1	0.3056
p.R571S	TCGA-W3-A828	SKCM	TCGA	ITPRDS	DEG_SCF_FBW7_1	0.6316
p.R571S	DO51273	SKCM	ICGC	ITPRDS	DEG_SCF_FBW7_1	0.6316
p.E563K	DO222908	MELA	ICGC	ITPRDS	DEG_SCF_FBW7_1	0.1944
p.G574D	SIDM00340	Plasma Cell Myeloma	GDSC	ITPRDS	DEG_SCF_FBW7_1	0.3056
p.G574D	ACH-000204	Myeloma	CCLE	ITPRDS	DEG_SCF_FBW7_1	0.3056
p.G574D	LP-1	haematopoietic_and_lymphoid_tissue	COSMIC	ITPRDS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86VW1	Solute carrier family 22 member 16	DEG_SCF_FBW7_1	568:573	ITPRDS	FBXW7	0.8613	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons