DegronMD - Q86VZ5(SGMS1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G96C	TCGA-55-7911	LUAD	TCGA	IPTPDGS	DEG_SCF_FBW7_1	91:97	Mutation altering degron motif	0.6489
p.G96C	DO24821	LUAD	ICGC	IPTPDGS	DEG_SCF_FBW7_1	91:97	Mutation altering degron motif	0.6489
p.I87N	TCGA-EE-A2MP	SKCM	TCGA	IPTPDGS	DEG_SCF_FBW7_1	91:97	Mutation rewiring degron network	0.2222
p.I87N	DO37818	SKCM	ICGC	IPTPDGS	DEG_SCF_FBW7_1	91:97	Mutation rewiring degron network	0.2222
p.S99N	DO233264	GACA	ICGC	IPTPDGS	DEG_SCF_FBW7_1	91:97	Mutation rewiring degron network	0.2778
p.M91I	DO15430	HNSC	ICGC	IPTPDGS	DEG_SCF_FBW7_1	91:97	Mutation altering degron motif	0.7618
p.M91I	DO50287	SKCM	ICGC	IPTPDGS	DEG_SCF_FBW7_1	91:97	Mutation altering degron motif	0.7618
p.M91I	DO219503	SKCM	ICGC	IPTPDGS	DEG_SCF_FBW7_1	91:97	Mutation altering degron motif	0.7618
p.N105K	DO228985	LICA	ICGC	IPTPDGS	DEG_SCF_FBW7_1	91:97	Mutation rewiring degron network	0.1111
p.P94T	DO228986	LICA	ICGC	IPTPDGS	DEG_SCF_FBW7_1	91:97	Mutation altering degron motif	0.7031
p.D95E	DO229031	LICA	ICGC	IPTPDGS	DEG_SCF_FBW7_1	91:97	Mutation altering degron motif	0.5647
p.G81E	DO220877	MELA	ICGC	IPTPDGS	DEG_SCF_FBW7_1	91:97	Mutation rewiring degron network	0.0556
p.P94S	DO229453	SKCA	ICGC	IPTPDGS	DEG_SCF_FBW7_1	91:97	Mutation altering degron motif	0.6752
p.R88Q	DO37567	SKCM	ICGC	IPTPDGS	DEG_SCF_FBW7_1	91:97	Mutation rewiring degron network	0.25
p.R88Q	DO50301	SKCM	ICGC	IPTPDGS	DEG_SCF_FBW7_1	91:97	Mutation rewiring degron network	0.25
p.L93F	DO48665	SKCM	ICGC	IPTPDGS	DEG_SCF_FBW7_1	91:97	Mutation altering degron motif	0.6981
p.E84D	DO229272	THCA	ICGC	IPTPDGS	DEG_SCF_FBW7_1	91:97	Mutation rewiring degron network	0.1389
p.I102T	Daudi	haematopoietic and lymphoid tissue	COSMIC	IPTPDGS	DEG_SCF_FBW7_1	91:97	Mutation rewiring degron network	0.1944

Kaplan plot for SGMS1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SGMS1

UniProt ID: Q86VZ5

Entrez ID: 259230

Protein name: Phosphatidylcholine:ceramide cholinephosphotransferase 1 (EC 2.7.8.27) (Medulla oblongata-derived protein) (Protein Mob) (Sphingomyelin synthase 1) (Transmembrane protein 23)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SGMS1 in