DegronMD

Uniprot ID: Q86VZ5

Source protein: Phosphatidylcholine:ceramide cholinephosphotransferase 1

Source gene: SGMS1

Class: DEG_SCF_FBW7_1

Location: 91:97

E3 ligase: FBXW7

DEGRON score: 0.8871

ASA_SCORE: 61.2857

COIL: 0.8004

CONS_SCORE: 0.2852

DSS_SCORE: 0.4066

HELIX: 0.0329

FCONS_SCORE: 0.9542

RIG_SCORE: 0.6948

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G96C	TCGA-55-7911	LUAD	TCGA	IPTPDGS	DEG_SCF_FBW7_1	0.6489
p.G96C	DO24821	LUAD	ICGC	IPTPDGS	DEG_SCF_FBW7_1	0.6489
p.I87N	TCGA-EE-A2MP	SKCM	TCGA	IPTPDGS	DEG_SCF_FBW7_1	0.2222
p.I87N	DO37818	SKCM	ICGC	IPTPDGS	DEG_SCF_FBW7_1	0.2222
p.S99N	DO233264	GACA	ICGC	IPTPDGS	DEG_SCF_FBW7_1	0.2778
p.M91I	DO15430	HNSC	ICGC	IPTPDGS	DEG_SCF_FBW7_1	0.7618
p.M91I	DO50287	SKCM	ICGC	IPTPDGS	DEG_SCF_FBW7_1	0.7618
p.M91I	DO219503	SKCM	ICGC	IPTPDGS	DEG_SCF_FBW7_1	0.7618
p.N105K	DO228985	LICA	ICGC	IPTPDGS	DEG_SCF_FBW7_1	0.1111
p.P94T	DO228986	LICA	ICGC	IPTPDGS	DEG_SCF_FBW7_1	0.7031
p.D95E	DO229031	LICA	ICGC	IPTPDGS	DEG_SCF_FBW7_1	0.5647
p.G81E	DO220877	MELA	ICGC	IPTPDGS	DEG_SCF_FBW7_1	0.0556
p.P94S	DO229453	SKCA	ICGC	IPTPDGS	DEG_SCF_FBW7_1	0.6752
p.R88Q	DO37567	SKCM	ICGC	IPTPDGS	DEG_SCF_FBW7_1	0.25
p.R88Q	DO50301	SKCM	ICGC	IPTPDGS	DEG_SCF_FBW7_1	0.25
p.L93F	DO48665	SKCM	ICGC	IPTPDGS	DEG_SCF_FBW7_1	0.6981
p.E84D	DO229272	THCA	ICGC	IPTPDGS	DEG_SCF_FBW7_1	0.1389
p.I102T	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	IPTPDGS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86VZ5	Phosphatidylcholine:ceramide cholinephosphotransferase 1	DEG_SCF_FBW7_1	91:97	IPTPDGS	FBXW7	0.8871	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons