DegronMD - Q86WD7(SERPINA9)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F407L	TCGA-61-2012	OV	TCGA	NRTFLMMIT	DEG_APCC_DBOX_1	390:398	Mutation rewiring degron network	0.0833
p.K391M	TCGA-78-8660	LUAD	TCGA	NRTFLMMIT	DEG_APCC_DBOX_1	390:398	Mutation altering degron motif	0.8062
p.P400S	TCGA-86-7954	LUAD	TCGA	NRTFLMMIT	DEG_APCC_DBOX_1	390:398	Mutation rewiring degron network	0.2778
p.P400S	TCGA-EE-A3AF	SKCM	TCGA	NRTFLMMIT	DEG_APCC_DBOX_1	390:398	Mutation rewiring degron network	0.2778
p.A384V	TCGA-A5-A0G2	UCEC	TCGA	NRTFLMMIT	DEG_APCC_DBOX_1	390:398	Mutation rewiring degron network	0.1667
p.A386V	TCGA-AD-6895	COAD	TCGA	NRTFLMMIT	DEG_APCC_DBOX_1	390:398	Mutation rewiring degron network	0.2222
p.T385A	TCGA-D1-A17Q	UCEC	TCGA	NRTFLMMIT	DEG_APCC_DBOX_1	390:398	Mutation rewiring degron network	0.1944
p.S401Y	TCGA-YL-A8HM	PRAD	TCGA	NRTFLMMIT	DEG_APCC_DBOX_1	390:398	Mutation rewiring degron network	0.25
p.G404S	DO227536	COCA	ICGC	NRTFLMMIT	DEG_APCC_DBOX_1	390:398	Mutation rewiring degron network	0.1667
p.T392N	DO228952	LICA	ICGC	NRTFLMMIT	DEG_APCC_DBOX_1	390:398	Mutation altering degron motif	0.5944
p.T402A	DO218922	LUAD	ICGC	NRTFLMMIT	DEG_APCC_DBOX_1	390:398	Mutation rewiring degron network	0.2222
p.P382S	DO23660	LUAD	ICGC	NRTFLMMIT	DEG_APCC_DBOX_1	390:398	Mutation rewiring degron network	0.1111
p.P382S	DO37911	SKCM	ICGC	NRTFLMMIT	DEG_APCC_DBOX_1	390:398	Mutation rewiring degron network	0.1111
p.S388F	DO222494	MELA	ICGC	NRTFLMMIT	DEG_APCC_DBOX_1	390:398	Mutation rewiring degron network	0.2778
p.L408Q	DO222632	MELA	ICGC	NRTFLMMIT	DEG_APCC_DBOX_1	390:398	Mutation rewiring degron network	0.0556
p.L408Q	DO37571	SKCM	ICGC	NRTFLMMIT	DEG_APCC_DBOX_1	390:398	Mutation rewiring degron network	0.0556
p.F389L	DO32536	OV	ICGC	NRTFLMMIT	DEG_APCC_DBOX_1	390:398	Mutation rewiring degron network	0.3056
p.M396I	DO29740	OV	ICGC	NRTFLMMIT	DEG_APCC_DBOX_1	390:398	Mutation altering degron motif	0.6507
p.S383Y	DO51419	PRAD	ICGC	NRTFLMMIT	DEG_APCC_DBOX_1	390:398	Mutation rewiring degron network	0.1389
p.T390N	SIDM00884	Breast Carcinoma	GDSC	NRTFLMMIT	DEG_APCC_DBOX_1	390:398	Mutation altering degron motif	0.7055
p.T390N	SIDM00886	B-Cell Non-Hodgkin's Lymphoma	GDSC	NRTFLMMIT	DEG_APCC_DBOX_1	390:398	Mutation altering degron motif	0.7055
p.T390N	HCC1395	breast	COSMIC	NRTFLMMIT	DEG_APCC_DBOX_1	390:398	Mutation altering degron motif	0.7055
p.T390N	DB	haematopoietic and lymphoid tissue	COSMIC	NRTFLMMIT	DEG_APCC_DBOX_1	390:398	Mutation altering degron motif	0.7055
p.K391Q	SIDM00886	B-Cell Non-Hodgkin's Lymphoma	GDSC	NRTFLMMIT	DEG_APCC_DBOX_1	390:398	Mutation altering degron motif	0.6944
p.K391Q	DB	haematopoietic and lymphoid tissue	COSMIC	NRTFLMMIT	DEG_APCC_DBOX_1	390:398	Mutation altering degron motif	0.6944
p.G399V	SIDM00290	Gastric Carcinoma	GDSC	NRTFLMMIT	DEG_APCC_DBOX_1	390:398	Mutation rewiring degron network	0.3056
p.G399V	HGC-27	stomach	COSMIC	NRTFLMMIT	DEG_APCC_DBOX_1	390:398	Mutation rewiring degron network	0.3056
p.D398N	SIDM01443	Gastric Carcinoma	GDSC	NRTFLMMIT	DEG_APCC_DBOX_1	390:398	Mutation altering degron motif	0.6932
p.D380N	ACH-000344	Gastric Cancer	CCLE	NRTFLMMIT	DEG_APCC_DBOX_1	390:398	Mutation rewiring degron network	0.0556
p.L408V	ACH-000724	Bladder Cancer	CCLE	NRTFLMMIT	DEG_APCC_DBOX_1	390:398	Mutation rewiring degron network	0.0556
p.L408V	HT-1376	urinary tract	COSMIC	NRTFLMMIT	DEG_APCC_DBOX_1	390:398	Mutation rewiring degron network	0.0556
p.G381V	ACH-000847	Gastric Cancer	CCLE	NRTFLMMIT	DEG_APCC_DBOX_1	390:398	Mutation rewiring degron network	0.0833
p.G381V	HGC-27	stomach	COSMIC	NRTFLMMIT	DEG_APCC_DBOX_1	390:398	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SERPINA9

UniProt ID: Q86WD7

Entrez ID: 327657

Protein name: Serpin A9 (Centerin) (Germinal center B-cell-expressed transcript 1 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SERPINA9 in