DegronMD

Uniprot ID: Q86WD7

Source protein: Serpin A9

Source gene: SERPINA9

Class: DEG_APCC_DBOX_1

Location: 390:398

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5198

ASA_SCORE: 18.3889

COIL: 0.2759

CONS_SCORE: 0.5863

DSS_SCORE: 0.0883

HELIX: 0.0022

FCONS_SCORE: 1.3706

RIG_SCORE: 0.9299

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F407L	TCGA-61-2012	OV	TCGA	NRTFLMMIT	DEG_APCC_DBOX_1	0.0833
p.K391M	TCGA-78-8660	LUAD	TCGA	NRTFLMMIT	DEG_APCC_DBOX_1	0.8062
p.P400S	TCGA-86-7954	LUAD	TCGA	NRTFLMMIT	DEG_APCC_DBOX_1	0.2778
p.P400S	TCGA-EE-A3AF	SKCM	TCGA	NRTFLMMIT	DEG_APCC_DBOX_1	0.2778
p.A384V	TCGA-A5-A0G2	UCEC	TCGA	NRTFLMMIT	DEG_APCC_DBOX_1	0.1667
p.A386V	TCGA-AD-6895	COAD	TCGA	NRTFLMMIT	DEG_APCC_DBOX_1	0.2222
p.T385A	TCGA-D1-A17Q	UCEC	TCGA	NRTFLMMIT	DEG_APCC_DBOX_1	0.1944
p.S401Y	TCGA-YL-A8HM	PRAD	TCGA	NRTFLMMIT	DEG_APCC_DBOX_1	0.25
p.G404S	DO227536	COCA	ICGC	NRTFLMMIT	DEG_APCC_DBOX_1	0.1667
p.T392N	DO228952	LICA	ICGC	NRTFLMMIT	DEG_APCC_DBOX_1	0.5944
p.T402A	DO218922	LUAD	ICGC	NRTFLMMIT	DEG_APCC_DBOX_1	0.2222
p.P382S	DO23660	LUAD	ICGC	NRTFLMMIT	DEG_APCC_DBOX_1	0.1111
p.P382S	DO37911	SKCM	ICGC	NRTFLMMIT	DEG_APCC_DBOX_1	0.1111
p.S388F	DO222494	MELA	ICGC	NRTFLMMIT	DEG_APCC_DBOX_1	0.2778
p.L408Q	DO222632	MELA	ICGC	NRTFLMMIT	DEG_APCC_DBOX_1	0.0556
p.L408Q	DO37571	SKCM	ICGC	NRTFLMMIT	DEG_APCC_DBOX_1	0.0556
p.F389L	DO32536	OV	ICGC	NRTFLMMIT	DEG_APCC_DBOX_1	0.3056
p.M396I	DO29740	OV	ICGC	NRTFLMMIT	DEG_APCC_DBOX_1	0.6507
p.S383Y	DO51419	PRAD	ICGC	NRTFLMMIT	DEG_APCC_DBOX_1	0.1389
p.T390N	SIDM00884	Breast Carcinoma	GDSC	NRTFLMMIT	DEG_APCC_DBOX_1	0.7055
p.T390N	SIDM00886	B-Cell Non-Hodgkin's Lymphoma	GDSC	NRTFLMMIT	DEG_APCC_DBOX_1	0.7055
p.T390N	HCC1395	breast	COSMIC	NRTFLMMIT	DEG_APCC_DBOX_1	0.7055
p.T390N	DB	haematopoietic_and_lymphoid_tissue	COSMIC	NRTFLMMIT	DEG_APCC_DBOX_1	0.7055
p.K391Q	SIDM00886	B-Cell Non-Hodgkin's Lymphoma	GDSC	NRTFLMMIT	DEG_APCC_DBOX_1	0.6944
p.K391Q	DB	haematopoietic_and_lymphoid_tissue	COSMIC	NRTFLMMIT	DEG_APCC_DBOX_1	0.6944
p.G399V	SIDM00290	Gastric Carcinoma	GDSC	NRTFLMMIT	DEG_APCC_DBOX_1	0.3056
p.G399V	HGC-27	stomach	COSMIC	NRTFLMMIT	DEG_APCC_DBOX_1	0.3056
p.D398N	SIDM01443	Gastric Carcinoma	GDSC	NRTFLMMIT	DEG_APCC_DBOX_1	0.6932
p.D380N	ACH-000344	Gastric Cancer	CCLE	NRTFLMMIT	DEG_APCC_DBOX_1	0.0556
p.L408V	ACH-000724	Bladder Cancer	CCLE	NRTFLMMIT	DEG_APCC_DBOX_1	0.0556
p.L408V	HT-1376	urinary_tract	COSMIC	NRTFLMMIT	DEG_APCC_DBOX_1	0.0556
p.G381V	ACH-000847	Gastric Cancer	CCLE	NRTFLMMIT	DEG_APCC_DBOX_1	0.0833
p.G381V	HGC-27	stomach	COSMIC	NRTFLMMIT	DEG_APCC_DBOX_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NRTFLMMIT

Degron related mutations and impact score

Drug responses associated with SERPINA9 mutations

All proteins holding degron of NRTFLMMIT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86WD7	Serpin A9	DEG_APCC_DBOX_1	390:398	NRTFLMMIT	APC,CDC20,FZR1	0.5198	More...