DegronMD - Q86WI3(NLRC5)

NLRC5

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M1543T	TCGA-A8-A09A	BRCA	TCGA	KRLDLSHLL	DEG_APCC_DBOX_1	1553:1561	Mutation rewiring degron network	0.0556
p.M1543T	DO2955	BRCA	ICGC	KRLDLSHLL	DEG_APCC_DBOX_1	1553:1561	Mutation rewiring degron network	0.0556
p.E1571Q	DO219727	CESC	ICGC	KRLDLSHLL	DEG_APCC_DBOX_1	1553:1561	Mutation rewiring degron network	0.0556
p.L1567F	DO229028	LICA	ICGC	KRLDLSHLL	DEG_APCC_DBOX_1	1553:1561	Mutation rewiring degron network	0.1667
p.S1565F	DO222647	MELA	ICGC	KRLDLSHLL	DEG_APCC_DBOX_1	1553:1561	Mutation rewiring degron network	0.2222
p.G1562C	NCI-H810	lung	COSMIC	KRLDLSHLL	DEG_APCC_DBOX_1	1553:1561	Mutation rewiring degron network	0.3056
p.G1562S	SCC90	upper aerodigestive tract	COSMIC	KRLDLSHLL	DEG_APCC_DBOX_1	1553:1561	Mutation rewiring degron network	0.3056
p.R1555K	HCC1937	breast	COSMIC	KRLDLSHLL	DEG_APCC_DBOX_1	1553:1561	Mutation altering degron motif	0.7237
p.Q1547R	KCL-22	haematopoietic and lymphoid tissue	COSMIC	KRLDLSHLL	DEG_APCC_DBOX_1	1553:1561	Mutation rewiring degron network	0.1667

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*NOTE: the Kaplan plots were collected from OncoLnc