DegronMD

Uniprot ID: Q86WI3

Source protein: Protein NLRC5

Source gene: NLRC5

Class: DEG_APCC_DBOX_1

Location: 1553:1561

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5148

ASA_SCORE: 75.3333

COIL: 0.6218

CONS_SCORE: 0.341

DSS_SCORE: 0.04

HELIX: 0.1161

FCONS_SCORE: 0.9976

RIG_SCORE: 0.8696

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M1543T	TCGA-A8-A09A	BRCA	TCGA	KRLDLSHLL	DEG_APCC_DBOX_1	0.0556
p.M1543T	DO2955	BRCA	ICGC	KRLDLSHLL	DEG_APCC_DBOX_1	0.0556
p.E1571Q	DO219727	CESC	ICGC	KRLDLSHLL	DEG_APCC_DBOX_1	0.0556
p.L1567F	DO229028	LICA	ICGC	KRLDLSHLL	DEG_APCC_DBOX_1	0.1667
p.S1565F	DO222647	MELA	ICGC	KRLDLSHLL	DEG_APCC_DBOX_1	0.2222
p.G1562C	NCI-H810	lung	COSMIC	KRLDLSHLL	DEG_APCC_DBOX_1	0.3056
p.G1562S	SCC90	upper_aerodigestive_tract	COSMIC	KRLDLSHLL	DEG_APCC_DBOX_1	0.3056
p.R1555K	HCC1937	breast	COSMIC	KRLDLSHLL	DEG_APCC_DBOX_1	0.7237
p.Q1547R	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	KRLDLSHLL	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86WI3	Protein NLRC5	DEG_APCC_DBOX_1	1553:1561	KRLDLSHLL	APC,CDC20,FZR1	0.5148	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons