FUNCTION: DNA helicase which plays a role in chromatin-remodeling following DNA damage (PubMed:19661379, PubMed:29220653). Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair (PubMed:19661379). Able to catalyze nucleosome sl...
FUNCTION: DNA helicase which plays a role in chromatin-remodeling following DNA damage (PubMed:19661379, PubMed:29220653). Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair (PubMed:19661379). Able to catalyze nucleosome sliding in an ATP-dependent manner (PubMed:19661379). Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding (PubMed:19661379, PubMed:29220653). {ECO:0000269|PubMed:19661379, ECO:0000269|PubMed:29220653}.
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GO - Biological processes (BP):
cellular response to DNA damage stimulus [GO:0006974]; chromatin remodeling [GO:0006338]; DNA repair [GO:0006281]...
cellular response to DNA damage stimulus [GO:0006974]; chromatin remodeling [GO:0006338]; DNA repair [GO:0006281]
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GO - Molecular function (MF):
ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; ATP hydrolysis activity [GO:0016887]; DNA helicase activity [GO:0003678]; nucleotide binding [GO:0000166]...
ATP binding [GO:0005524]; ATP-dependent chromatin remodeler activity [GO:0140658]; ATP hydrolysis activity [GO:0016887]; DNA helicase activity [GO:0003678]; nucleotide binding [GO:0000166]
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GO - Cellular component (CC):
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]...
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]
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