DegronMD

Uniprot ID: Q86WJ1

Source protein: Chromodomain-helicase-DNA-binding protein 1-like

Source gene: CHD1L

Class: LIG_APCC_ABBA_1

Location: 18:23

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8501

ASA_SCORE: 105.8

COIL: 0.7787

CONS_SCORE: 0.2746

DSS_SCORE: 0.4513

HELIX: 0.1753

FCONS_SCORE: 0.8972

RIG_SCORE: 0.7907

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R25P	DO230334	COCA	ICGC	LRLHTE	LIG_APCC_ABBA_1	0.2778
p.R25P	DO229013	COCA	ICGC	LRLHTE	LIG_APCC_ABBA_1	0.2778
p.R25P	DO229005	COCA	ICGC	LRLHTE	LIG_APCC_ABBA_1	0.2778
p.A29T	DO233207	GACA	ICGC	LRLHTE	LIG_APCC_ABBA_1	0.1667
p.G24V	DO229275	THCA	ICGC	LRLHTE	LIG_APCC_ABBA_1	0.3056
p.E33K	SIDM00006	Other Solid Cancers	GDSC	LRLHTE	LIG_APCC_ABBA_1	0.0556
p.C25S	MDA-MB-157	breast	COSMIC	LRLHTE	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86WJ1	Chromodomain-helicase-DNA-binding protein 1-like	LIG_APCC_ABBA_1	18:23	LRLHTE	APC,CDC20,FZR1	0.8501	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons