DegronMD - Q86WK7(AMIGO3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K447N	TCGA-A5-A0G1	UCEC	TCGA	KHVVFLE	LIG_APCC_ABBAyCdc20_2	452:458	Mutation substituting flanking lysine	0.3056
p.K447N	DO42472	UCEC	ICGC	KHVVFLE	LIG_APCC_ABBAyCdc20_2	452:458	Mutation substituting flanking lysine	0.3056
p.V454I	TCGA-A5-A0G2	UCEC	TCGA	KHVVFLE	LIG_APCC_ABBAyCdc20_2	452:458	Mutation altering degron motif	0.5965
p.V454I	DO41235	UCEC	ICGC	KHVVFLE	LIG_APCC_ABBAyCdc20_2	452:458	Mutation altering degron motif	0.5965
p.V454I	SIDM01612	Endometrial Carcinoma	GDSC	KHVVFLE	LIG_APCC_ABBAyCdc20_2	452:458	Mutation altering degron motif	0.5965
p.V454I	ACH-000946	Endometrial/Uterine Cancer	CCLE	KHVVFLE	LIG_APCC_ABBAyCdc20_2	452:458	Mutation altering degron motif	0.5965
p.R461W	TCGA-A5-A0VP	UCEC	TCGA	KHVVFLE	LIG_APCC_ABBAyCdc20_2	452:458	Mutation rewiring degron network	0.25
p.R461W	DO42600	UCEC	ICGC	KHVVFLE	LIG_APCC_ABBAyCdc20_2	452:458	Mutation rewiring degron network	0.25
p.N465S	TCGA-BQ-5888	KIRP	TCGA	KHVVFLE	LIG_APCC_ABBAyCdc20_2	452:458	Mutation rewiring degron network	0.1389
p.N465S	DO20772	KIRP	ICGC	KHVVFLE	LIG_APCC_ABBAyCdc20_2	452:458	Mutation rewiring degron network	0.1389
p.H453Y	TCGA-DF-A2KN	UCEC	TCGA	KHVVFLE	LIG_APCC_ABBAyCdc20_2	452:458	Mutation altering degron motif	0.6118
p.H453Y	DO223282	UCEC	ICGC	KHVVFLE	LIG_APCC_ABBAyCdc20_2	452:458	Mutation altering degron motif	0.6118
p.V468M	TCGA-DF-A2KU	UCEC	TCGA	KHVVFLE	LIG_APCC_ABBAyCdc20_2	452:458	Mutation rewiring degron network	0.0556
p.V468M	DO223286	UCEC	ICGC	KHVVFLE	LIG_APCC_ABBAyCdc20_2	452:458	Mutation rewiring degron network	0.0556
p.R461Q	DO230335	COCA	ICGC	KHVVFLE	LIG_APCC_ABBAyCdc20_2	452:458	Mutation rewiring degron network	0.25
p.P444R	DO46538	OV	ICGC	KHVVFLE	LIG_APCC_ABBAyCdc20_2	452:458	Mutation rewiring degron network	0.1111
p.R446C	SIDM00602	Gastric Carcinoma	GDSC	KHVVFLE	LIG_APCC_ABBAyCdc20_2	452:458	Mutation rewiring degron network	0.1667
p.R446C	ACH-000919	Gastric Cancer	CCLE	KHVVFLE	LIG_APCC_ABBAyCdc20_2	452:458	Mutation rewiring degron network	0.1667
p.R446C	IM-95	stomach	COSMIC	KHVVFLE	LIG_APCC_ABBAyCdc20_2	452:458	Mutation rewiring degron network	0.1667
p.R446H	SIDM00213	Thyroid Gland Carcinoma	GDSC	KHVVFLE	LIG_APCC_ABBAyCdc20_2	452:458	Mutation rewiring degron network	0.1667
p.R446H	ACH-000903	Thyroid Cancer	CCLE	KHVVFLE	LIG_APCC_ABBAyCdc20_2	452:458	Mutation rewiring degron network	0.1667
p.R446H	FTC-133	thyroid	COSMIC	KHVVFLE	LIG_APCC_ABBAyCdc20_2	452:458	Mutation rewiring degron network	0.1667

Kaplan plot for AMIGO3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AMIGO3

UniProt ID: Q86WK7

Entrez ID: 386724

Protein name: Amphoterin-induced protein 3 (AMIGO-3) (Alivin-3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AMIGO3 in