DegronMD

Uniprot ID: Q86WK7

Source protein: Amphoterin-induced protein 3

Source gene: AMIGO3

Class: LIG_APCC_ABBAyCdc20_2

Location: 452:458

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9548

ASA_SCORE: 71.3

COIL: 0.6351

CONS_SCORE: 0.8698

DSS_SCORE: 0.4118

HELIX: 0.0293

FCONS_SCORE: 1.4237

RIG_SCORE: 0.8086

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K447N	TCGA-A5-A0G1	UCEC	TCGA	KHVVFLE	LIG_APCC_ABBAyCdc20_2	0.3056
p.K447N	DO42472	UCEC	ICGC	KHVVFLE	LIG_APCC_ABBAyCdc20_2	0.3056
p.V454I	TCGA-A5-A0G2	UCEC	TCGA	KHVVFLE	LIG_APCC_ABBAyCdc20_2	0.5965
p.V454I	DO41235	UCEC	ICGC	KHVVFLE	LIG_APCC_ABBAyCdc20_2	0.5965
p.V454I	SIDM01612	Endometrial Carcinoma	GDSC	KHVVFLE	LIG_APCC_ABBAyCdc20_2	0.5965
p.V454I	ACH-000946	Endometrial/Uterine Cancer	CCLE	KHVVFLE	LIG_APCC_ABBAyCdc20_2	0.5965
p.R461W	TCGA-A5-A0VP	UCEC	TCGA	KHVVFLE	LIG_APCC_ABBAyCdc20_2	0.25
p.R461W	DO42600	UCEC	ICGC	KHVVFLE	LIG_APCC_ABBAyCdc20_2	0.25
p.N465S	TCGA-BQ-5888	KIRP	TCGA	KHVVFLE	LIG_APCC_ABBAyCdc20_2	0.1389
p.N465S	DO20772	KIRP	ICGC	KHVVFLE	LIG_APCC_ABBAyCdc20_2	0.1389
p.H453Y	TCGA-DF-A2KN	UCEC	TCGA	KHVVFLE	LIG_APCC_ABBAyCdc20_2	0.6118
p.H453Y	DO223282	UCEC	ICGC	KHVVFLE	LIG_APCC_ABBAyCdc20_2	0.6118
p.V468M	TCGA-DF-A2KU	UCEC	TCGA	KHVVFLE	LIG_APCC_ABBAyCdc20_2	0.0556
p.V468M	DO223286	UCEC	ICGC	KHVVFLE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R461Q	DO230335	COCA	ICGC	KHVVFLE	LIG_APCC_ABBAyCdc20_2	0.25
p.P444R	DO46538	OV	ICGC	KHVVFLE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R446C	SIDM00602	Gastric Carcinoma	GDSC	KHVVFLE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R446C	ACH-000919	Gastric Cancer	CCLE	KHVVFLE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R446C	IM-95	stomach	COSMIC	KHVVFLE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R446H	SIDM00213	Thyroid Gland Carcinoma	GDSC	KHVVFLE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R446H	ACH-000903	Thyroid Cancer	CCLE	KHVVFLE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R446H	FTC-133	thyroid	COSMIC	KHVVFLE	LIG_APCC_ABBAyCdc20_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86WK7	Amphoterin-induced protein 3	LIG_APCC_ABBAyCdc20_2	452:458	KHVVFLE	APC,CDC20,FZR1	0.9548	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons