DegronMD - Q86WR6(C17orf64)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P232Q	TCGA-37-3789	LUSC	TCGA	PETPETE	DEG_SCF_FBW7_2	229:235	Mutation altering degron motif	0.7035
p.P232Q	DO26743	LUSC	ICGC	PETPETE	DEG_SCF_FBW7_2	229:235	Mutation altering degron motif	0.7035
p.P229Q	TCGA-66-2791	LUSC	TCGA	PETPETE	DEG_SCF_FBW7_2	229:235	Mutation altering degron motif	0.7035
p.P229Q	DO26435	LUSC	ICGC	PETPETE	DEG_SCF_FBW7_2	229:235	Mutation altering degron motif	0.7035
p.R224M	TCGA-BK-A6W3	UCEC	TCGA	PETPETE	DEG_SCF_FBW7_2	229:235	Mutation rewiring degron network	0.1944
p.R224M	DO222608	BTCA	ICGC	PETPETE	DEG_SCF_FBW7_2	229:235	Mutation rewiring degron network	0.1944
p.R224M	DO50076	UCEC	ICGC	PETPETE	DEG_SCF_FBW7_2	229:235	Mutation rewiring degron network	0.1944
p.A228V	DO50970	LICA	ICGC	PETPETE	DEG_SCF_FBW7_2	229:235	Mutation rewiring degron network	0.3056
p.P229S	DO222494	MELA	ICGC	PETPETE	DEG_SCF_FBW7_2	229:235	Mutation altering degron motif	0.6752
p.E235V	DO27959	ORCA	ICGC	PETPETE	DEG_SCF_FBW7_2	229:235	Mutation altering degron motif	0.7693
p.P236L	SIDM00087	Plasma Cell Myeloma	GDSC	PETPETE	DEG_SCF_FBW7_2	229:235	Mutation rewiring degron network	0.3056

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons