DegronMD

Uniprot ID: Q86WR6

Source protein: Uncharacterized protein C17orf64

Source gene: C17orf64

Class: DEG_SCF_FBW7_2

Location: 229:235

E3 ligase: FBXW7

DEGRON score: 0.5628

ASA_SCORE: 116.0857

COIL: 0.9413

CONS_SCORE: 0.6521

DSS_SCORE: 0.9059

HELIX: 0.0171

FCONS_SCORE: 0.7851

RIG_SCORE: 0.617

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P232Q	TCGA-37-3789	LUSC	TCGA	PETPETE	DEG_SCF_FBW7_2	0.7035
p.P232Q	DO26743	LUSC	ICGC	PETPETE	DEG_SCF_FBW7_2	0.7035
p.P229Q	TCGA-66-2791	LUSC	TCGA	PETPETE	DEG_SCF_FBW7_2	0.7035
p.P229Q	DO26435	LUSC	ICGC	PETPETE	DEG_SCF_FBW7_2	0.7035
p.R224M	TCGA-BK-A6W3	UCEC	TCGA	PETPETE	DEG_SCF_FBW7_2	0.1944
p.R224M	DO222608	BTCA	ICGC	PETPETE	DEG_SCF_FBW7_2	0.1944
p.R224M	DO50076	UCEC	ICGC	PETPETE	DEG_SCF_FBW7_2	0.1944
p.A228V	DO50970	LICA	ICGC	PETPETE	DEG_SCF_FBW7_2	0.3056
p.P229S	DO222494	MELA	ICGC	PETPETE	DEG_SCF_FBW7_2	0.6752
p.E235V	DO27959	ORCA	ICGC	PETPETE	DEG_SCF_FBW7_2	0.7693
p.P236L	SIDM00087	Plasma Cell Myeloma	GDSC	PETPETE	DEG_SCF_FBW7_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86WR6	Uncharacterized protein C17orf64	DEG_SCF_FBW7_2	229:235	PETPETE	FBXW7	0.5628	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons