DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
PROSER2
UniProt ID:
Q86WR7
Entrez ID:
254427
Protein name:
Proline and serine-rich protein 2
External links:
UniprotKB
HGNC
RefSeq
COSMIC
Please click
HERE
for better display.
Functional annotation
Mutations
Degrons
Degron mutations
Network-rewiring
Drug response
Drug resistance
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GO - Biological processes (BP):
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GO - Molecular function (MF):
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GO - Cellular component (CC):
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Choose a PDB ID:
Open in full screen with detailed sequence annotations
PROSER2
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ICGC
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CCLE
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Phosphorylation
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AAchange
Cancer
Sample
Mutation type
Dataset
Degron hit
Class
E3 ligase
Source protein
Location
Detail
Mutation
Sample
Cancer
Degron hit
Class
Location
Dataset
Mutation
Sample
Cancer
Dataset
Degron hit
Class
Location
Type
Impact score
p.L428V
ACH-000113
Leukemia
CCLE
RREALRKLG
DEG_APCC_DBOX_1
421:429
Mutation altering degron motif
0.5654
p.R414H
ACH-001674
Neuroblastoma
CCLE
RREALRKLG
DEG_APCC_DBOX_1
421:429
Mutation rewiring degron network
0.1389
Cell ID
Cell name
Cancer
Drug
IC50(uM)
Dataset
Protein
Degron
Cancer code
Cancer type
Drug
AVG_IC50(uM)(mutated)
AVG_IC50(uM)(Non-mutated)
Details
Kaplan plot for PROSER2 in
Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from
OncoLnc