DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
RREALRKLG
Uniprot ID:
Q86WR7
Source protein:
Proline and serine-rich protein 2
Source gene:
PROSER2
Class:
DEG_APCC_DBOX_1
Location:
421:429
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8815
ASA_SCORE:
65.7333
COIL:
0.2113
CONS_SCORE:
0.9965
DSS_SCORE:
0.5005
HELIX:
0.7851
FCONS_SCORE:
1.1155
RIG_SCORE:
0.7783
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.L428V
ACH-000113
Leukemia
CCLE
RREALRKLG
DEG_APCC_DBOX_1
0.5654
p.R414H
ACH-001674
Neuroblastoma
CCLE
RREALRKLG
DEG_APCC_DBOX_1
0.1389
Drug responses associated with PROSER2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of RREALRKLG
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q86WR7
Proline and serine-rich protein 2
DEG_APCC_DBOX_1
421:429
RREALRKLG
APC,CDC20,FZR1
0.8815
More...