DegronMD - Q86WS4(C12orf40)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E403K	TCGA-55-7907	LUAD	TCGA	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	412:419	Mutation rewiring degron network	0.0833
p.E403K	DO25396	LUAD	ICGC	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	412:419	Mutation rewiring degron network	0.0833
p.P425S	TCGA-A6-5661	COAD	TCGA	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	412:419	Mutation rewiring degron network	0.1667
p.P425S	DO8634	COAD	ICGC	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	412:419	Mutation rewiring degron network	0.1667
p.P425S	SIDM00217	Colorectal Carcinoma	GDSC	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	412:419	Mutation rewiring degron network	0.1667
p.P425S	ACH-000999	Colon/Colorectal Cancer	CCLE	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	412:419	Mutation rewiring degron network	0.1667
p.E414Q	TCGA-AO-A03M	BRCA	TCGA	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	412:419	Mutation altering degron motif	0.6744
p.E414Q	DO2216	BRCA	ICGC	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	412:419	Mutation altering degron motif	0.6744
p.E414D	TCGA-B5-A0JY	UCEC	TCGA	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	412:419	Mutation altering degron motif	0.5647
p.E414D	DO43041	UCEC	ICGC	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	412:419	Mutation altering degron motif	0.5647
p.N410D	TCGA-BR-8679	STAD	TCGA	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	412:419	Mutation rewiring degron network	0.2778
p.N410D	DO47875	STAD	ICGC	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	412:419	Mutation rewiring degron network	0.2778
p.M429T	TCGA-CN-A63U	HNSC	TCGA	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	412:419	Mutation rewiring degron network	0.0556
p.M429T	DO44454	HNSC	ICGC	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	412:419	Mutation rewiring degron network	0.0556
p.P417Q	TCGA-D3-A2JC	SKCM	TCGA	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	412:419	Mutation altering degron motif	0.7035
p.P417Q	DO47578	SKCM	ICGC	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	412:419	Mutation altering degron motif	0.7035
p.E403D	TCGA-EO-A3AV	UCEC	TCGA	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	412:419	Mutation rewiring degron network	0.0833
p.E403D	DO52412	UCEC	ICGC	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	412:419	Mutation rewiring degron network	0.0833
p.K419E	DO231673	LINC	ICGC	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	412:419	Mutation altering degron motif	0.7022
p.M429V	SIDM00403	T-Lymphoblastic Leukemia	GDSC	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	412:419	Mutation rewiring degron network	0.0556
p.S402C	SIDM00969	Ovarian Carcinoma	GDSC	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	412:419	Mutation rewiring degron network	0.0556
p.S402C	SIDM00087	Plasma Cell Myeloma	GDSC	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	412:419	Mutation rewiring degron network	0.0556
p.S402C	SIDM00654	Small Cell Lung Carcinoma	GDSC	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	412:419	Mutation rewiring degron network	0.0556
p.S402C	SIDM01118	Small Cell Lung Carcinoma	GDSC	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	412:419	Mutation rewiring degron network	0.0556
p.S402C	SIDM00032	Bladder Carcinoma	GDSC	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	412:419	Mutation rewiring degron network	0.0556
p.S402C	SIDM00907	Burkitt's Lymphoma	GDSC	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	412:419	Mutation rewiring degron network	0.0556
p.S402C	SIDM01147	Gastric Carcinoma	GDSC	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	412:419	Mutation rewiring degron network	0.0556
p.S402C	SIDM01387	Small Cell Lung Carcinoma	GDSC	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	412:419	Mutation rewiring degron network	0.0556
p.Q422K	SIDM00193	Colorectal Carcinoma	GDSC	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	412:419	Mutation rewiring degron network	0.25
p.Q422K	ACH-000991	Colon/Colorectal Cancer	CCLE	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	412:419	Mutation rewiring degron network	0.25
p.E409K	SIDM00227	Neuroblastoma	GDSC	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	412:419	Mutation rewiring degron network	0.25
p.E409K	ACH-001344	Neuroblastoma	CCLE	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	412:419	Mutation rewiring degron network	0.25
p.S428C	SIDM00562	Breast Carcinoma	GDSC	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	412:419	Mutation rewiring degron network	0.0833
p.S428C	ACH-002163	Breast Cancer	CCLE	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	412:419	Mutation rewiring degron network	0.0833
p.M429L	SIDM00049	Colorectal Carcinoma	GDSC	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	412:419	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

C12orf40

UniProt ID: Q86WS4

Entrez ID: 283461

Protein name: Uncharacterized protein C12orf40

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for C12orf40 in