DegronMD

Uniprot ID: Q86WS4

Source protein: Uncharacterized protein C12orf40

Source gene: C12orf40

Class: DEG_SCF_SKP2-CKS1_1

Location: 412:419

E3 ligase: SKP2,CSK1

DEGRON score: 0.9966

ASA_SCORE: 111.65

COIL: 0.7724

CONS_SCORE: 0.4427

DSS_SCORE: 0.6377

HELIX: 0.1861

FCONS_SCORE: 1.0736

RIG_SCORE: 0.6997

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E403K	TCGA-55-7907	LUAD	TCGA	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	0.0833
p.E403K	DO25396	LUAD	ICGC	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	0.0833
p.P425S	TCGA-A6-5661	COAD	TCGA	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	0.1667
p.P425S	DO8634	COAD	ICGC	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	0.1667
p.P425S	SIDM00217	Colorectal Carcinoma	GDSC	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	0.1667
p.P425S	ACH-000999	Colon/Colorectal Cancer	CCLE	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	0.1667
p.E414Q	TCGA-AO-A03M	BRCA	TCGA	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	0.6744
p.E414Q	DO2216	BRCA	ICGC	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	0.6744
p.E414D	TCGA-B5-A0JY	UCEC	TCGA	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	0.5647
p.E414D	DO43041	UCEC	ICGC	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	0.5647
p.N410D	TCGA-BR-8679	STAD	TCGA	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	0.2778
p.N410D	DO47875	STAD	ICGC	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	0.2778
p.M429T	TCGA-CN-A63U	HNSC	TCGA	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	0.0556
p.M429T	DO44454	HNSC	ICGC	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	0.0556
p.P417Q	TCGA-D3-A2JC	SKCM	TCGA	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	0.7035
p.P417Q	DO47578	SKCM	ICGC	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	0.7035
p.E403D	TCGA-EO-A3AV	UCEC	TCGA	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	0.0833
p.E403D	DO52412	UCEC	ICGC	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	0.0833
p.K419E	DO231673	LINC	ICGC	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	0.7022
p.M429V	SIDM00403	T-Lymphoblastic Leukemia	GDSC	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	0.0556
p.S402C	SIDM00969	Ovarian Carcinoma	GDSC	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	0.0556
p.S402C	SIDM00087	Plasma Cell Myeloma	GDSC	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	0.0556
p.S402C	SIDM00654	Small Cell Lung Carcinoma	GDSC	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	0.0556
p.S402C	SIDM01118	Small Cell Lung Carcinoma	GDSC	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	0.0556
p.S402C	SIDM00032	Bladder Carcinoma	GDSC	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	0.0556
p.S402C	SIDM00907	Burkitt's Lymphoma	GDSC	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	0.0556
p.S402C	SIDM01147	Gastric Carcinoma	GDSC	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	0.0556
p.S402C	SIDM01387	Small Cell Lung Carcinoma	GDSC	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	0.0556
p.Q422K	SIDM00193	Colorectal Carcinoma	GDSC	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	0.25
p.Q422K	ACH-000991	Colon/Colorectal Cancer	CCLE	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	0.25
p.E409K	SIDM00227	Neuroblastoma	GDSC	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	0.25
p.E409K	ACH-001344	Neuroblastoma	CCLE	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	0.25
p.S428C	SIDM00562	Breast Carcinoma	GDSC	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	0.0833
p.S428C	ACH-002163	Breast Cancer	CCLE	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	0.0833
p.M429L	SIDM00049	Colorectal Carcinoma	GDSC	YQEKTPQK	DEG_SCF_SKP2-CKS1_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: YQEKTPQK

Degron related mutations and impact score

Drug responses associated with C12orf40 mutations

All proteins holding degron of YQEKTPQK

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86WS4	Uncharacterized protein C12orf40	DEG_SCF_SKP2-CKS1_1	412:419	YQEKTPQK	SKP2,CSK1	0.9966	More...