DegronMD - Q86XH1(IQCA1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R459K	TCGA-A5-A0G2	UCEC	TCGA	MRQELKNLK	DEG_APCC_DBOX_1	444:452	Mutation rewiring degron network	0.1389
p.S434L	TCGA-A5-A0G2	UCEC	TCGA	MRQELKNLK	DEG_APCC_DBOX_1	444:452	Mutation blocking phosphorylation signal	0.5
p.R459S	TCGA-AX-A1CE	UCEC	TCGA	MRQELKNLK	DEG_APCC_DBOX_1	444:452	Mutation rewiring degron network	0.1389
p.M444I	TCGA-BH-A0EE	BRCA	TCGA	MRQELKNLK	DEG_APCC_DBOX_1	444:452	Mutation altering degron motif	0.6507
p.D456A	TCGA-BP-4985	KIRC	TCGA	MRQELKNLK	DEG_APCC_DBOX_1	444:452	Mutation rewiring degron network	0.2222
p.V440L	TCGA-XF-AAMY	BLCA	TCGA	MRQELKNLK	DEG_APCC_DBOX_1	444:452	Mutation rewiring degron network	0.2222
p.V436L	DO219050	BLCA	ICGC	MRQELKNLK	DEG_APCC_DBOX_1	444:452	Mutation rewiring degron network	0.1111
p.M440I	DO6088	BRCA	ICGC	MRQELKNLK	DEG_APCC_DBOX_1	444:452	Mutation rewiring degron network	0.2222
p.R457H	DO229016	COCA	ICGC	MRQELKNLK	DEG_APCC_DBOX_1	444:452	Mutation rewiring degron network	0.1944
p.D452A	DO20693	KIRC	ICGC	MRQELKNLK	DEG_APCC_DBOX_1	444:452	Mutation altering degron motif	0.7793
p.A461E	DO229019	LICA	ICGC	MRQELKNLK	DEG_APCC_DBOX_1	444:452	Mutation rewiring degron network	0.0833
p.Q442E	DO221128	MALY	ICGC	MRQELKNLK	DEG_APCC_DBOX_1	444:452	Mutation rewiring degron network	0.2778
p.G462E	DO37404	SKCM	ICGC	MRQELKNLK	DEG_APCC_DBOX_1	444:452	Mutation rewiring degron network	0.0556
p.R455S	DO42280	UCEC	ICGC	MRQELKNLK	DEG_APCC_DBOX_1	444:452	Mutation rewiring degron network	0.25
p.R455K	DO41235	UCEC	ICGC	MRQELKNLK	DEG_APCC_DBOX_1	444:452	Mutation rewiring degron network	0.25
p.R436Q	SIDM00545	Melanoma	GDSC	MRQELKNLK	DEG_APCC_DBOX_1	444:452	Mutation rewiring degron network	0.1111
p.R436Q	Mewo	skin	COSMIC	MRQELKNLK	DEG_APCC_DBOX_1	444:452	Mutation rewiring degron network	0.1111
p.E449Q	SIDM01735	Biliary Tract Carcinoma	GDSC	MRQELKNLK	DEG_APCC_DBOX_1	444:452	Mutation altering degron motif	0.6744
p.E460K	ACH-000699	Breast Cancer	CCLE	MRQELKNLK	DEG_APCC_DBOX_1	444:452	Mutation rewiring degron network	0.1111
p.E460K	HCC1395	breast	COSMIC	MRQELKNLK	DEG_APCC_DBOX_1	444:452	Mutation rewiring degron network	0.1111
p.E442Q	ACH-000808	Bile Duct Cancer	CCLE	MRQELKNLK	DEG_APCC_DBOX_1	444:452	Mutation rewiring degron network	0.2778
p.R461C	ACH-000974	Endometrial/Uterine Cancer	CCLE	MRQELKNLK	DEG_APCC_DBOX_1	444:452	Mutation rewiring degron network	0.0833
p.R461C	ACH-002026	Endometrial/Uterine Cancer	CCLE	MRQELKNLK	DEG_APCC_DBOX_1	444:452	Mutation rewiring degron network	0.0833
p.R461C	SNG-M	endometrium	COSMIC	MRQELKNLK	DEG_APCC_DBOX_1	444:452	Mutation rewiring degron network	0.0833

Kaplan plot for IQCA1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IQCA1

UniProt ID: Q86XH1

Entrez ID: 79781

Protein name: Dynein regulatory complex protein 11 (IQ and AAA domain-containing protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IQCA1 in