DegronMD

Uniprot ID: Q86XH1

Source protein: Dynein regulatory complex protein 11

Source gene: IQCA1

Class: DEG_APCC_DBOX_1

Location: 444:452

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5545

ASA_SCORE: 80.0889

COIL: 0.1028

CONS_SCORE: 0.5702

DSS_SCORE: 0.3289

HELIX: 0.8936

FCONS_SCORE: 1.1738

RIG_SCORE: 0.8057

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R459K	TCGA-A5-A0G2	UCEC	TCGA	MRQELKNLK	DEG_APCC_DBOX_1	0.1389
p.S434L	TCGA-A5-A0G2	UCEC	TCGA	MRQELKNLK	DEG_APCC_DBOX_1	0.5
p.R459S	TCGA-AX-A1CE	UCEC	TCGA	MRQELKNLK	DEG_APCC_DBOX_1	0.1389
p.M444I	TCGA-BH-A0EE	BRCA	TCGA	MRQELKNLK	DEG_APCC_DBOX_1	0.6507
p.D456A	TCGA-BP-4985	KIRC	TCGA	MRQELKNLK	DEG_APCC_DBOX_1	0.2222
p.V440L	TCGA-XF-AAMY	BLCA	TCGA	MRQELKNLK	DEG_APCC_DBOX_1	0.2222
p.V436L	DO219050	BLCA	ICGC	MRQELKNLK	DEG_APCC_DBOX_1	0.1111
p.M440I	DO6088	BRCA	ICGC	MRQELKNLK	DEG_APCC_DBOX_1	0.2222
p.R457H	DO229016	COCA	ICGC	MRQELKNLK	DEG_APCC_DBOX_1	0.1944
p.D452A	DO20693	KIRC	ICGC	MRQELKNLK	DEG_APCC_DBOX_1	0.7793
p.A461E	DO229019	LICA	ICGC	MRQELKNLK	DEG_APCC_DBOX_1	0.0833
p.Q442E	DO221128	MALY	ICGC	MRQELKNLK	DEG_APCC_DBOX_1	0.2778
p.G462E	DO37404	SKCM	ICGC	MRQELKNLK	DEG_APCC_DBOX_1	0.0556
p.R455S	DO42280	UCEC	ICGC	MRQELKNLK	DEG_APCC_DBOX_1	0.25
p.R455K	DO41235	UCEC	ICGC	MRQELKNLK	DEG_APCC_DBOX_1	0.25
p.R436Q	SIDM00545	Melanoma	GDSC	MRQELKNLK	DEG_APCC_DBOX_1	0.1111
p.R436Q	Mewo	skin	COSMIC	MRQELKNLK	DEG_APCC_DBOX_1	0.1111
p.E449Q	SIDM01735	Biliary Tract Carcinoma	GDSC	MRQELKNLK	DEG_APCC_DBOX_1	0.6744
p.E460K	ACH-000699	Breast Cancer	CCLE	MRQELKNLK	DEG_APCC_DBOX_1	0.1111
p.E460K	HCC1395	breast	COSMIC	MRQELKNLK	DEG_APCC_DBOX_1	0.1111
p.E442Q	ACH-000808	Bile Duct Cancer	CCLE	MRQELKNLK	DEG_APCC_DBOX_1	0.2778
p.R461C	ACH-000974	Endometrial/Uterine Cancer	CCLE	MRQELKNLK	DEG_APCC_DBOX_1	0.0833
p.R461C	ACH-002026	Endometrial/Uterine Cancer	CCLE	MRQELKNLK	DEG_APCC_DBOX_1	0.0833
p.R461C	SNG-M	endometrium	COSMIC	MRQELKNLK	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86XH1	Dynein regulatory complex protein 11	DEG_APCC_DBOX_1	444:452	MRQELKNLK	APC,CDC20,FZR1	0.5545	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons