DegronMD - Q86XT2(VPS37D)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P211S	TCGA-D5-6535	COAD	TCGA	FPAAAVLPT	DEG_SIAH_1	193:201	Mutation rewiring degron network	0.0556
p.P211S	DO10397	COAD	ICGC	FPAAAVLPT	DEG_SIAH_1	193:201	Mutation rewiring degron network	0.0556
p.R205Q	TCGA-F4-6856	COAD	TCGA	FPAAAVLPT	DEG_SIAH_1	193:201	Mutation rewiring degron network	0.2222
p.R205Q	DO9114	COAD	ICGC	FPAAAVLPT	DEG_SIAH_1	193:201	Mutation rewiring degron network	0.2222
p.V198A	TCGA-F7-A624	HNSC	TCGA	FPAAAVLPT	DEG_SIAH_1	193:201	Mutation altering degron motif	0.6936
p.V198A	DO44440	HNSC	ICGC	FPAAAVLPT	DEG_SIAH_1	193:201	Mutation altering degron motif	0.6936
p.A209V	TCGA-RC-A6M4	LIHC	TCGA	FPAAAVLPT	DEG_SIAH_1	193:201	Mutation rewiring degron network	0.1111
p.A209V	DO223915	LIHC	ICGC	FPAAAVLPT	DEG_SIAH_1	193:201	Mutation rewiring degron network	0.1111
p.T184I	TCGA-T2-A6X2	HNSC	TCGA	FPAAAVLPT	DEG_SIAH_1	193:201	Mutation rewiring degron network	0.0833
p.T184I	DO219071	HNSC	ICGC	FPAAAVLPT	DEG_SIAH_1	193:201	Mutation rewiring degron network	0.0833
p.L199M	DO229259	THCA	ICGC	FPAAAVLPT	DEG_SIAH_1	193:201	Mutation altering degron motif	0.5999
p.P208T	DO229234	THCA	ICGC	FPAAAVLPT	DEG_SIAH_1	193:201	Mutation rewiring degron network	0.1389
p.R205L	SIDM02039	Colorectal Carcinoma	GDSC	FPAAAVLPT	DEG_SIAH_1	193:201	Mutation rewiring degron network	0.2222
p.F193L	SIDM00814	Other Solid Cancers	GDSC	FPAAAVLPT	DEG_SIAH_1	193:201	Mutation altering degron motif	0.587
p.F193L	ACH-001401	Adrenal Cancer	CCLE	FPAAAVLPT	DEG_SIAH_1	193:201	Mutation altering degron motif	0.587
p.F193L	SW13	adrenal gland	COSMIC	FPAAAVLPT	DEG_SIAH_1	193:201	Mutation altering degron motif	0.587

Kaplan plot for VPS37D in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

VPS37D

UniProt ID: Q86XT2

Entrez ID: 155382

Protein name: Vacuolar protein sorting-associated protein 37D (ESCRT-I complex subunit VPS37D) (Williams-Beuren syndrome chromosomal region 24 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for VPS37D in