DegronMD

Uniprot ID: Q86XT2

Source protein: Vacuolar protein sorting-associated protein 37D

Source gene: VPS37D

Class: DEG_SIAH_1

Location: 193:201

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9777

ASA_SCORE: 64.1111

COIL: 0.8883

CONS_SCORE: 0.5331

DSS_SCORE: 0.6194

HELIX: 0.039

FCONS_SCORE: 1.1053

RIG_SCORE: 0.6565

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P211S	TCGA-D5-6535	COAD	TCGA	FPAAAVLPT	DEG_SIAH_1	0.0556
p.P211S	DO10397	COAD	ICGC	FPAAAVLPT	DEG_SIAH_1	0.0556
p.R205Q	TCGA-F4-6856	COAD	TCGA	FPAAAVLPT	DEG_SIAH_1	0.2222
p.R205Q	DO9114	COAD	ICGC	FPAAAVLPT	DEG_SIAH_1	0.2222
p.V198A	TCGA-F7-A624	HNSC	TCGA	FPAAAVLPT	DEG_SIAH_1	0.6936
p.V198A	DO44440	HNSC	ICGC	FPAAAVLPT	DEG_SIAH_1	0.6936
p.A209V	TCGA-RC-A6M4	LIHC	TCGA	FPAAAVLPT	DEG_SIAH_1	0.1111
p.A209V	DO223915	LIHC	ICGC	FPAAAVLPT	DEG_SIAH_1	0.1111
p.T184I	TCGA-T2-A6X2	HNSC	TCGA	FPAAAVLPT	DEG_SIAH_1	0.0833
p.T184I	DO219071	HNSC	ICGC	FPAAAVLPT	DEG_SIAH_1	0.0833
p.L199M	DO229259	THCA	ICGC	FPAAAVLPT	DEG_SIAH_1	0.5999
p.P208T	DO229234	THCA	ICGC	FPAAAVLPT	DEG_SIAH_1	0.1389
p.R205L	SIDM02039	Colorectal Carcinoma	GDSC	FPAAAVLPT	DEG_SIAH_1	0.2222
p.F193L	SIDM00814	Other Solid Cancers	GDSC	FPAAAVLPT	DEG_SIAH_1	0.587
p.F193L	ACH-001401	Adrenal Cancer	CCLE	FPAAAVLPT	DEG_SIAH_1	0.587
p.F193L	SW13	adrenal_gland	COSMIC	FPAAAVLPT	DEG_SIAH_1	0.587

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86XT2	Vacuolar protein sorting-associated protein 37D	DEG_SIAH_1	193:201	FPAAAVLPT	SIAH1,SIAH2,SIAH3	0.9777	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons