DegronMD - Q86XX4(FRAS1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D2077G	TCGA-AZ-4315	COAD	TCGA	RMKIYTE	LIG_APCC_ABBAyCdc20_2	2066:2072	Mutation rewiring degron network	0.1944
p.D2077G	DO8842	COAD	ICGC	RMKIYTE	LIG_APCC_ABBAyCdc20_2	2066:2072	Mutation rewiring degron network	0.1944
p.G2065W	TCGA-BR-4188	STAD	TCGA	RMKIYTE	LIG_APCC_ABBAyCdc20_2	2066:2072	Mutation rewiring degron network	0.3056
p.G2065W	DO38312	STAD	ICGC	RMKIYTE	LIG_APCC_ABBAyCdc20_2	2066:2072	Mutation rewiring degron network	0.3056
p.P2074S	TCGA-EO-A3AV	UCEC	TCGA	RMKIYTE	LIG_APCC_ABBAyCdc20_2	2066:2072	Mutation rewiring degron network	0.2778
p.P2074S	DO52412	UCEC	ICGC	RMKIYTE	LIG_APCC_ABBAyCdc20_2	2066:2072	Mutation rewiring degron network	0.2778
p.P2074H	TCGA-FS-A1ZR	SKCM	TCGA	RMKIYTE	LIG_APCC_ABBAyCdc20_2	2066:2072	Mutation rewiring degron network	0.2778
p.P2074H	DO37651	SKCM	ICGC	RMKIYTE	LIG_APCC_ABBAyCdc20_2	2066:2072	Mutation rewiring degron network	0.2778
p.H2061Q	TCGA-XK-AAIV	PRAD	TCGA	RMKIYTE	LIG_APCC_ABBAyCdc20_2	2066:2072	Mutation rewiring degron network	0.1944
p.H2061Q	DO51405	PRAD	ICGC	RMKIYTE	LIG_APCC_ABBAyCdc20_2	2066:2072	Mutation rewiring degron network	0.1944
p.D2063Y	DO228971	LICA	ICGC	RMKIYTE	LIG_APCC_ABBAyCdc20_2	2066:2072	Mutation rewiring degron network	0.25
p.S2076I	DO229025	LICA	ICGC	RMKIYTE	LIG_APCC_ABBAyCdc20_2	2066:2072	Mutation rewiring degron network	0.2222
p.R2066S	DO229041	LICA	ICGC	RMKIYTE	LIG_APCC_ABBAyCdc20_2	2066:2072	Mutation altering degron motif	0.7427
p.D2063N	DO220891	MELA	ICGC	RMKIYTE	LIG_APCC_ABBAyCdc20_2	2066:2072	Mutation rewiring degron network	0.25
p.T2064I	SIDM00983	Bladder Carcinoma	GDSC	RMKIYTE	LIG_APCC_ABBAyCdc20_2	2066:2072	Mutation rewiring degron network	0.2778
p.T2064I	ACH-000896	Bladder Cancer	CCLE	RMKIYTE	LIG_APCC_ABBAyCdc20_2	2066:2072	Mutation rewiring degron network	0.2778
p.T2064I	647-V	urinary tract	COSMIC	RMKIYTE	LIG_APCC_ABBAyCdc20_2	2066:2072	Mutation rewiring degron network	0.2778

Kaplan plot for FRAS1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FRAS1

UniProt ID: Q86XX4

Entrez ID: 80144

Protein name: Extracellular matrix organizing protein FRAS1 (Fraser syndrome 1 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FRAS1 in