DegronMD

Uniprot ID: Q86XX4

Source protein: Extracellular matrix organizing protein FRAS1

Source gene: FRAS1

Class: LIG_APCC_ABBAyCdc20_2

Location: 2066:2072

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6812

ASA_SCORE: 49.4143

COIL: 0.0299

CONS_SCORE: 0.5331

DSS_SCORE: 0.336

HELIX: 0.002

FCONS_SCORE: 0.9135

RIG_SCORE: 0.834

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D2077G	TCGA-AZ-4315	COAD	TCGA	RMKIYTE	LIG_APCC_ABBAyCdc20_2	0.1944
p.D2077G	DO8842	COAD	ICGC	RMKIYTE	LIG_APCC_ABBAyCdc20_2	0.1944
p.G2065W	TCGA-BR-4188	STAD	TCGA	RMKIYTE	LIG_APCC_ABBAyCdc20_2	0.3056
p.G2065W	DO38312	STAD	ICGC	RMKIYTE	LIG_APCC_ABBAyCdc20_2	0.3056
p.P2074S	TCGA-EO-A3AV	UCEC	TCGA	RMKIYTE	LIG_APCC_ABBAyCdc20_2	0.2778
p.P2074S	DO52412	UCEC	ICGC	RMKIYTE	LIG_APCC_ABBAyCdc20_2	0.2778
p.P2074H	TCGA-FS-A1ZR	SKCM	TCGA	RMKIYTE	LIG_APCC_ABBAyCdc20_2	0.2778
p.P2074H	DO37651	SKCM	ICGC	RMKIYTE	LIG_APCC_ABBAyCdc20_2	0.2778
p.H2061Q	TCGA-XK-AAIV	PRAD	TCGA	RMKIYTE	LIG_APCC_ABBAyCdc20_2	0.1944
p.H2061Q	DO51405	PRAD	ICGC	RMKIYTE	LIG_APCC_ABBAyCdc20_2	0.1944
p.D2063Y	DO228971	LICA	ICGC	RMKIYTE	LIG_APCC_ABBAyCdc20_2	0.25
p.S2076I	DO229025	LICA	ICGC	RMKIYTE	LIG_APCC_ABBAyCdc20_2	0.2222
p.R2066S	DO229041	LICA	ICGC	RMKIYTE	LIG_APCC_ABBAyCdc20_2	0.7427
p.D2063N	DO220891	MELA	ICGC	RMKIYTE	LIG_APCC_ABBAyCdc20_2	0.25
p.T2064I	SIDM00983	Bladder Carcinoma	GDSC	RMKIYTE	LIG_APCC_ABBAyCdc20_2	0.2778
p.T2064I	ACH-000896	Bladder Cancer	CCLE	RMKIYTE	LIG_APCC_ABBAyCdc20_2	0.2778
p.T2064I	647-V	urinary_tract	COSMIC	RMKIYTE	LIG_APCC_ABBAyCdc20_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86XX4	Extracellular matrix organizing protein FRAS1	LIG_APCC_ABBAyCdc20_2	2066:2072	RMKIYTE	APC,CDC20,FZR1	0.6812	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons