DegronMD - Q86Y22(COL23A1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R110L	TCGA-D3-A3CE	SKCM	TCGA	LREKLDGLA	DEG_APCC_DBOX_1	96:104	Mutation rewiring degron network	0.1667
p.R110L	TCGA-EE-A29E	SKCM	TCGA	LREKLDGLA	DEG_APCC_DBOX_1	96:104	Mutation rewiring degron network	0.1667
p.R110L	DO37831	SKCM	ICGC	LREKLDGLA	DEG_APCC_DBOX_1	96:104	Mutation rewiring degron network	0.1667
p.R110L	DO37405	SKCM	ICGC	LREKLDGLA	DEG_APCC_DBOX_1	96:104	Mutation rewiring degron network	0.1667
p.G102R	DO51009	LAML	ICGC	LREKLDGLA	DEG_APCC_DBOX_1	96:104	Mutation altering degron motif	0.6457
p.R110W	DO222875	MELA	ICGC	LREKLDGLA	DEG_APCC_DBOX_1	96:104	Mutation rewiring degron network	0.1667
p.R107W	SIDM01962	Colorectal Carcinoma	GDSC	LREKLDGLA	DEG_APCC_DBOX_1	96:104	Mutation rewiring degron network	0.25
p.A104E	SIDM00133	Non-Small Cell Lung Carcinoma	GDSC	LREKLDGLA	DEG_APCC_DBOX_1	96:104	Mutation altering degron motif	0.659
p.A104E	ACH-000861	Lung Cancer	CCLE	LREKLDGLA	DEG_APCC_DBOX_1	96:104	Mutation altering degron motif	0.659
p.A104E	HOP-62	lung	COSMIC	LREKLDGLA	DEG_APCC_DBOX_1	96:104	Mutation altering degron motif	0.659
p.G102E	SIDM00140	Melanoma	GDSC	LREKLDGLA	DEG_APCC_DBOX_1	96:104	Mutation altering degron motif	0.6087
p.G102E	ACH-000968	Skin Cancer	CCLE	LREKLDGLA	DEG_APCC_DBOX_1	96:104	Mutation altering degron motif	0.6087
p.G102E	COLO-792	skin	COSMIC	LREKLDGLA	DEG_APCC_DBOX_1	96:104	Mutation altering degron motif	0.6087

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons