DegronMD

Uniprot ID: Q86Y22

Source protein: Collagen alpha-1

Source gene: COL23A1

Class: DEG_APCC_DBOX_1

Location: 96:104

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8291

ASA_SCORE: 81.9556

COIL: 0.7546

CONS_SCORE: 0.9263

DSS_SCORE: 0.381

HELIX: 0.1956

FCONS_SCORE: 1.0047

RIG_SCORE: 0.7801

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R110L	TCGA-D3-A3CE	SKCM	TCGA	LREKLDGLA	DEG_APCC_DBOX_1	0.1667
p.R110L	TCGA-EE-A29E	SKCM	TCGA	LREKLDGLA	DEG_APCC_DBOX_1	0.1667
p.R110L	DO37831	SKCM	ICGC	LREKLDGLA	DEG_APCC_DBOX_1	0.1667
p.R110L	DO37405	SKCM	ICGC	LREKLDGLA	DEG_APCC_DBOX_1	0.1667
p.G102R	DO51009	LAML	ICGC	LREKLDGLA	DEG_APCC_DBOX_1	0.6457
p.R110W	DO222875	MELA	ICGC	LREKLDGLA	DEG_APCC_DBOX_1	0.1667
p.R107W	SIDM01962	Colorectal Carcinoma	GDSC	LREKLDGLA	DEG_APCC_DBOX_1	0.25
p.A104E	SIDM00133	Non-Small Cell Lung Carcinoma	GDSC	LREKLDGLA	DEG_APCC_DBOX_1	0.659
p.A104E	ACH-000861	Lung Cancer	CCLE	LREKLDGLA	DEG_APCC_DBOX_1	0.659
p.A104E	HOP-62	lung	COSMIC	LREKLDGLA	DEG_APCC_DBOX_1	0.659
p.G102E	SIDM00140	Melanoma	GDSC	LREKLDGLA	DEG_APCC_DBOX_1	0.6087
p.G102E	ACH-000968	Skin Cancer	CCLE	LREKLDGLA	DEG_APCC_DBOX_1	0.6087
p.G102E	COLO-792	skin	COSMIC	LREKLDGLA	DEG_APCC_DBOX_1	0.6087

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86Y22	Collagen alpha-1	DEG_APCC_DBOX_1	96:104	LREKLDGLA	APC,CDC20,FZR1	0.8291	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons