DegronMD - Q86Y26(NUTM1)

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GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G599D	TCGA-DI-A1BU	UCEC	TCGA	VSLHQD	LIG_APCC_ABBA_1	593:598	Mutation rewiring degron network	0.3056
p.G599D	DO42023	UCEC	ICGC	VSLHQD	LIG_APCC_ABBA_1	593:598	Mutation rewiring degron network	0.3056
p.G585W	TCGA-ER-A195	SKCM	TCGA	VSLHQD	LIG_APCC_ABBA_1	593:598	Mutation rewiring degron network	0.1111
p.G585W	DO47712	SKCM	ICGC	VSLHQD	LIG_APCC_ABBA_1	593:598	Mutation rewiring degron network	0.1111
p.G585W	ACH-000966	Ovarian Cancer	CCLE	VSLHQD	LIG_APCC_ABBA_1	593:598	Mutation rewiring degron network	0.1111
p.Q592K	TCGA-FS-A1ZJ	SKCM	TCGA	VSLHQD	LIG_APCC_ABBA_1	593:598	Mutation rewiring degron network	0.3056
p.Q592K	DO37956	SKCM	ICGC	VSLHQD	LIG_APCC_ABBA_1	593:598	Mutation rewiring degron network	0.3056
p.G585R	TCGA-IB-7651	PAAD	TCGA	VSLHQD	LIG_APCC_ABBA_1	593:598	Mutation rewiring degron network	0.1111
p.G585R	DO46657	PAAD	ICGC	VSLHQD	LIG_APCC_ABBA_1	593:598	Mutation rewiring degron network	0.1111
p.N591S	DO232027	LICA	ICGC	VSLHQD	LIG_APCC_ABBA_1	593:598	Mutation rewiring degron network	0.2778
p.G587R	DO220875	MELA	ICGC	VSLHQD	LIG_APCC_ABBA_1	593:598	Mutation rewiring degron network	0.1667
p.P588L	SIDM00455	Pancreatic Carcinoma	GDSC	VSLHQD	LIG_APCC_ABBA_1	593:598	Mutation substituting flanking lysine	0.3056
p.P588L	SIDM00270	Head and Neck Carcinoma	GDSC	VSLHQD	LIG_APCC_ABBA_1	593:598	Mutation substituting flanking lysine	0.3056
p.P588L	SIDM01201	Other Blood Cancers	GDSC	VSLHQD	LIG_APCC_ABBA_1	593:598	Mutation substituting flanking lysine	0.3056
p.P588L	SIDM00694	Other Solid Cancers	GDSC	VSLHQD	LIG_APCC_ABBA_1	593:598	Mutation substituting flanking lysine	0.3056
p.P588L	SIDM00793	Burkitt's Lymphoma	GDSC	VSLHQD	LIG_APCC_ABBA_1	593:598	Mutation substituting flanking lysine	0.3056
p.P588L	SIDM01229	Neuroblastoma	GDSC	VSLHQD	LIG_APCC_ABBA_1	593:598	Mutation substituting flanking lysine	0.3056
p.P588L	SIDM00721	Small Cell Lung Carcinoma	GDSC	VSLHQD	LIG_APCC_ABBA_1	593:598	Mutation substituting flanking lysine	0.3056
p.P588L	SIDM00808	Burkitt's Lymphoma	GDSC	VSLHQD	LIG_APCC_ABBA_1	593:598	Mutation substituting flanking lysine	0.3056
p.P588L	SIDM01725	Non-Cancerous	GDSC	VSLHQD	LIG_APCC_ABBA_1	593:598	Mutation substituting flanking lysine	0.3056
p.P588L	SIDM01752	Pancreatic Carcinoma	GDSC	VSLHQD	LIG_APCC_ABBA_1	593:598	Mutation substituting flanking lysine	0.3056
p.P588L	SIDM01254	Burkitt's Lymphoma	GDSC	VSLHQD	LIG_APCC_ABBA_1	593:598	Mutation substituting flanking lysine	0.3056
p.P606S	SIDM01750	Melanoma	GDSC	VSLHQD	LIG_APCC_ABBA_1	593:598	Mutation rewiring degron network	0.1111
p.P606L	SIDM01750	Melanoma	GDSC	VSLHQD	LIG_APCC_ABBA_1	593:598	Mutation rewiring degron network	0.1111
p.G587V	DEL	haematopoietic and lymphoid tissue	COSMIC	VSLHQD	LIG_APCC_ABBA_1	593:598	Mutation rewiring degron network	0.1667
p.G605V	DEL	haematopoietic and lymphoid tissue	COSMIC	VSLHQD	LIG_APCC_ABBA_1	593:598	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NUTM1

UniProt ID: Q86Y26

Entrez ID: 256646

Protein name: NUT family member 1 (Nuclear protein in testis)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NUTM1 in