DegronMD

Uniprot ID: Q86Y26

Source protein: NUT family member 1

Source gene: NUTM1

Class: LIG_APCC_ABBA_1

Location: 593:598

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9576

ASA_SCORE: 70.95

COIL: 0.7713

CONS_SCORE: 0.4814

DSS_SCORE: 0.5428

HELIX: 0.0635

FCONS_SCORE: 0.7282

RIG_SCORE: 0.7083

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G599D	TCGA-DI-A1BU	UCEC	TCGA	VSLHQD	LIG_APCC_ABBA_1	0.3056
p.G599D	DO42023	UCEC	ICGC	VSLHQD	LIG_APCC_ABBA_1	0.3056
p.G585W	TCGA-ER-A195	SKCM	TCGA	VSLHQD	LIG_APCC_ABBA_1	0.1111
p.G585W	DO47712	SKCM	ICGC	VSLHQD	LIG_APCC_ABBA_1	0.1111
p.G585W	ACH-000966	Ovarian Cancer	CCLE	VSLHQD	LIG_APCC_ABBA_1	0.1111
p.Q592K	TCGA-FS-A1ZJ	SKCM	TCGA	VSLHQD	LIG_APCC_ABBA_1	0.3056
p.Q592K	DO37956	SKCM	ICGC	VSLHQD	LIG_APCC_ABBA_1	0.3056
p.G585R	TCGA-IB-7651	PAAD	TCGA	VSLHQD	LIG_APCC_ABBA_1	0.1111
p.G585R	DO46657	PAAD	ICGC	VSLHQD	LIG_APCC_ABBA_1	0.1111
p.N591S	DO232027	LICA	ICGC	VSLHQD	LIG_APCC_ABBA_1	0.2778
p.G587R	DO220875	MELA	ICGC	VSLHQD	LIG_APCC_ABBA_1	0.1667
p.P588L	SIDM00455	Pancreatic Carcinoma	GDSC	VSLHQD	LIG_APCC_ABBA_1	0.3056
p.P588L	SIDM00270	Head and Neck Carcinoma	GDSC	VSLHQD	LIG_APCC_ABBA_1	0.3056
p.P588L	SIDM01201	Other Blood Cancers	GDSC	VSLHQD	LIG_APCC_ABBA_1	0.3056
p.P588L	SIDM00694	Other Solid Cancers	GDSC	VSLHQD	LIG_APCC_ABBA_1	0.3056
p.P588L	SIDM00793	Burkitt's Lymphoma	GDSC	VSLHQD	LIG_APCC_ABBA_1	0.3056
p.P588L	SIDM01229	Neuroblastoma	GDSC	VSLHQD	LIG_APCC_ABBA_1	0.3056
p.P588L	SIDM00721	Small Cell Lung Carcinoma	GDSC	VSLHQD	LIG_APCC_ABBA_1	0.3056
p.P588L	SIDM00808	Burkitt's Lymphoma	GDSC	VSLHQD	LIG_APCC_ABBA_1	0.3056
p.P588L	SIDM01725	Non-Cancerous	GDSC	VSLHQD	LIG_APCC_ABBA_1	0.3056
p.P588L	SIDM01752	Pancreatic Carcinoma	GDSC	VSLHQD	LIG_APCC_ABBA_1	0.3056
p.P588L	SIDM01254	Burkitt's Lymphoma	GDSC	VSLHQD	LIG_APCC_ABBA_1	0.3056
p.P606S	SIDM01750	Melanoma	GDSC	VSLHQD	LIG_APCC_ABBA_1	0.1111
p.P606L	SIDM01750	Melanoma	GDSC	VSLHQD	LIG_APCC_ABBA_1	0.1111
p.G587V	DEL	haematopoietic_and_lymphoid_tissue	COSMIC	VSLHQD	LIG_APCC_ABBA_1	0.1667
p.G605V	DEL	haematopoietic_and_lymphoid_tissue	COSMIC	VSLHQD	LIG_APCC_ABBA_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86Y26	NUT family member 1	LIG_APCC_ABBA_1	593:598	VSLHQD	APC,CDC20,FZR1	0.9576	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VSLHQD

Degron related mutations and impact score

Drug responses associated with NUTM1 mutations

All proteins holding degron of VSLHQD