KMT5C
UniProt ID: Q86Y97
Entrez ID: 84787
Protein name: Histone-lysine N-methyltransferase KMT5C (Lysine N-methyltransferase 5C) (Lysine-specific methyltransferase 5C) (Suppressor of variegation 4-20 homolog 2) (Su(var)4-20 homolog 2) (Suv4-20h2) ([histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.362) ([histone H4]-lysine20 N-methyltransferase KMT5B) (EC 2.1.1.361)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of ge...
FUNCTION: Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity (PubMed:24396869, PubMed:28114273). In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (PubMed:24396869). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5C is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (PubMed:28114273). May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity). {ECO:0000250|UniProtKB:Q6Q783, ECO:0000269|PubMed:24396869, ECO:0000269|PubMed:28114273}.
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GO - Biological processes (BP):
chromatin organization [GO:0006325]; DNA repair [GO:0006281]; histone H4-K20 dimethylation [GO:0034772]; histone H4-K20 trimethylation [GO:0034773]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of isotype switching [GO:0045830]...
chromatin organization [GO:0006325]; DNA repair [GO:0006281]; histone H4-K20 dimethylation [GO:0034772]; histone H4-K20 trimethylation [GO:0034773]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of isotype switching [GO:0045830]
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GO - Molecular function (MF):
chromatin binding [GO:0003682]; histone binding [GO:0042393]; histone-lysine N-methyltransferase activity [GO:0018024]; histone methyltransferase activity (H4-K20 specific) [GO:0042799]; metal ion binding [GO:0046872]; S-adenosyl-L-methionine binding [GO:1904047]...
chromatin binding [GO:0003682]; histone binding [GO:0042393]; histone-lysine N-methyltransferase activity [GO:0018024]; histone methyltransferase activity (H4-K20 specific) [GO:0042799]; metal ion binding [GO:0046872]; S-adenosyl-L-methionine binding [GO:1904047]
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GO - Cellular component (CC):
condensed chromosome, centromeric region [GO:0000779]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]...
condensed chromosome, centromeric region [GO:0000779]; heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]
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KMT5C
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Kaplan plot for KMT5C in
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*NOTE: the Kaplan plots were collected from OncoLnc